neoplasms Flashcards
1
Q
ear SCC invading cartilage staging
A
T4
2
Q
> 4 mm with ulceration melanoma
A
stage 2c
3
Q
hundreds disseminated KA
A
grzybowski
4
Q
adulthood larynx mucosa KA
A
gryzybowski
5
Q
maple leaf structure
A
pBCC
6
Q
p53 G1 cycle mutations
A
AK
7
Q
periungual SCC HPV
A
HPV 16
8
Q
Asian indians commonest skin ca
A
SCC
9
Q
red chapped liplaser
A
CO2
10
Q
SLN bx recommended for
A
intermediate thickness accurate staging
11
Q
giant CMN melanoma risk
A
6%,
12
Q
myotonic dystrophy aw
A
pilomatricomas,
13
Q
AK incidence reduced by
A
lo-fat diet
14
Q
HPV 6,11
A
genital wart
15
Q
Lmyc amplification
A
MCC
16
Q
intraoral melanoma location
A
hard palate
17
Q
pseudorosettes trabecular variant
A
MCC
18
Q
MCC margins head neck
A
3 cm
19
Q
NSE ACTH CD44
A
MCC
20
Q
MCC mets potential ?
A
Yes
21
Q
syringotropic MF biopsy
A
punch
22
Q
MM staging criteria
A
breslow ulceration
23
Q
MM women site
A
legs
24
Q
MM men site
A
back
25
spina bifida macrocephaly ododogenic cyst
gorlin
26
medulloblastoma
gorlin
27
poikilodermatous MF aw
LyP
28
imiquimod cytokines
IL1 5 6 8,
29
lowest recurrence AK site
mid forehead
30
cryo cure rate AK
99%,
31
celecoxib
UV chemopreventive
32
in MM p53 activate ___promotoe apoptosis inhibit ___
PUMA, bcl2
33
stage 4-MMnon visceral mets
better prognsosis
34
base nose UVR risk
cUVR
35
vimentin s100 HMB45
melanocytic
36
polyomavirus chromogranin NSE synaptotophysin ck20/8
MCC
37
pinkus BCC site
lumbosacral
38
SCC oral site commest
lateral tongue
39
epitheloid sarcoma sites
hands forearms
40
transplant? Risk skin ca
4x
41
risk in transplant in order
| melanoma bcc scc mcc
SCC>bcc>melanoma> MCC
42
organ transplant SCC
x65
43
Melanoma leukoderma
mets dz
44
prolong survival st 3/4 melanoma
ipilumumab
45
ipilumumab cytokines
TNF IFN-A IL2
46
CD34+ F13a-ve
DFSP
47
cytogeneitc reciprocal translocation t(17:22)(q22;q13)
DFSP
48
monoclonal gene rearrangement in
CTCL
49
denileukin difitox
CTCL systemic Rx-
50
SCC cryo temp
-50 deg
51
1 mucinous ca location
eyelid
52
pseudodarier
multiple leiomyoma
53
multiple leiomyoma ca link
RCC
54
SCC low risk location
chest
55
Chloroma aw
leukemia
56
SCC % recurrence excision
20%
57
bazex vs Rombo
hypohidrosis present in bazex
58
pagetoid reticulosis locaitons
hands feet,
59
MAC location
periorbital nasolabial perioral
60
CD31 CK CD34
angiosarcoma
61
diptheria fusion toxin IL2 rceptor
denileukin difitox
62
which B cell lymphoma express :
B-cell antigens (CD20, CD79a)+
absent t(14;18) translocation,
Bcl-2 -, Bcl-6 +
PCFCL
63
which B cell lymphoma has Predilection for the head, neck,
and trunk
Elderly patients
PCFCL
| "follicle is blackHEAD" vs "marginalized"
64
which B cell lymphoma has Predilection for trunk and
upper extremities
Younger patients (median age,
55 years)
Marginal zone lymphoma
65
The 5-year survival of PCFCL
favorable, with rates up to 95% in large studies.
66
which B cell lymphoma express :
CD20, CD79a+
Bcl-2 + Bcl-6 -
CD10-
PMZL
67
Bcl-2 + Bcl-6 -
PMZL ( does a 2+6- dance)
68
bcl2 -, bcl6+
PCFCL
69
which B cell lymphoma has poorer prognosis, 5-year survival rates of 50%
PCBCL-LT
70
2 main negative prognostic factors of PCBCL-LT
Location on the leg and the presence of
| multiple skin lesions a
71
which B cell lymphoma expresses
Bcl-2+, MUM1/IRF4+
immunoglobulin M, and FOX-P1+
PCDLBCL-LT
72
histology of B cell lymphomas - which have diffuse infiltrate but prognosis different!
PCDLBCL-LT( diffuse ) PCFCL
73
RT alone or in combination with R-CHOP are
first-line treatment for solitary, localized, or
generalized disease
PCDLBCL-LT( diffuse
74
A 56-year-old woman presented with a bluish-red 6-cm
nodule on the anterior aspect of her left shin. An incisional
biopsy specimen was obtained, and the histologic review
revealed a diffuse infiltrate of centroblasts and immunoblasts in confluent sheets.
2. Which of the following findings lends support to a
diagnosis with a more favorable prognosis?
Negative immunoglobulin M expression
diffuse infiltrate can be either PFCL or PDLPCDL BCL-LT
Strong
and widespread cytoplasmic immunoglobulin
M expression is characteristic of PCDLBCL-LT,whereas
PCFCL is negative for immunoglobulin M
75
treatment of primary cutaneous follicle center lymphoma
| Solitary/localized
Local radiotherapy and excision
76
Vemurafenib has a relatively short timeto response and improves overall survival in patients with melanoma
harboring a ? mutation.
a BRAF V600E mutation.
77
What Stage melanoma includes metastatic dis-ease in the regional lymph nodes, in-transit disease, or satellite metastases
Stage III melanoma
78
IFNa Common contraindications:
atrial fibrillation; depression,
with history of psychiatric
hospitalization or suicidality;
79
role of radiation as an adjuvant therapy for melanoma.
Adjuvant radiotherapy may be considered whenextracapsular extension is noted histologically inan effort to improve regional control
80
development of in-transit metastases places a patient at stage ?
stage IIIC
81
What may be considered for patients with in-transit metasta-ses localized to a single limb but too numerous to allow punch
excision or surgical resection
Isolated limb infusion or perfusion may beconsidered in effort to achieve locoregionalcontrol
82
Presence of dysplastic nevi are associated with increased
melanoma risk in individuals
83
Classic Spitz nevi size
<5-6 mm
84
Classic Spitz nevi age
<10 years old
85
Younger age is associated with ? behaving Spitz nevus
more likelybenign
86
? mutations in acquired nevi, superficial spreading melanomas(SSM), and nodular melanomas
BRAF
87
? mutations in Spitz nevi and Spitzoid lesions
HRAS
88
?mutations in congenital nevi,
NRAS
89
? alterations in acral and mucosal melanoma,
KIT
90
GNAQ and GNA11 mutations in
ocular melanoma and blue nevi.
91
In common Spitz nevus compared to mela-noma, Ki-67
HMB-45
S100-A6
In common Spitz nevus compared to mela-noma, Ki-67 is stained in fewer cells, HMB-45exhibits differential staining at certain le-sion depths, and S100-A6 is stained stronglyand diffusely
92
metastatic potential in questionable Spitz tumors most recent
study indicates that the three most important criteria are
mitotic activity,
| mitoses near the base, and inflammation
93
?is usually recommended for adultswith Spitz nevi
Excision
94
Common Spitz nevi in children may be managed
nonsurgically
95
Atypical Spitz tumors may require ?to guide management
sentinel node biopsy
96
approximate rate ofSLNB positivity would you expect to find for spitz tumors ?
40%
97
Classical spitz Which of the following statements is true if the lymph node is positive?
possible that the surgeon will suggest a complete lymphadenectomy
98
Organ transplant recipients have a ? increased risk for melanoma
three- to fivefold
99
The risk of squamous cell carcinoma devel-opment increases with
time post transplant
100
Patients with cutaneous T-cell lymphoma are susceptible to
S aureus infection
101
What is the most common site of primary
| extranodal lymphoma?
The most common primary site is the gastrointestinal
| tract followed by the skin
102
best treatment for indolent CBCLs
b. Surgery or radiation
103
Which of the following lipid lowering agents may
| impair renal function during cyclosporine treatmen
Fenofibrate
104
Dfsp ,follow-up is recommended
Because risk of recurrence is
| substantial,follow-up is recommended every 6 months for 5 years and then annually life.
105
imatinib mesylate therapy, a molecular-targeted therapy that inhibitsmultiple tyrosine kinases, including the
PDGFb receptor tyrosine kinase that is overactive in DFSP.
106
proliferating pilar cyst course
Slow growth with potential malignant
107
Porokeratosis reason for increased propensity to cancer development is unknown, the candidate gene implicated in DSAP,
SART3, is a tumor rejection antigen, suggesting one possiblemechanism for neoplastic transformation
108
Acquired ichthyosis commonest malignancy
Hodgkin disease
109
Acquired icthyosis
| Implicated medications
cimetidine
nicotinic acid
haloperidol
clofazimine
110
most common site of metastasis is
the trunk
111
Long-term risk EAI involves:
Squamous cell carcinoma
| Merkel cell carcinoma
112
Cutaneous involvement of internal malignancies occurs in what percentage of patients?
1% to 9%
113
most common cause of cutaneous metastasis in men?
Bronchogenic carcinoma
114
treatment leiomyoma multiple includes
Cold avoidance
Gabapentin
Intralesional botulinum toxin
Nifedipine
115
Re granular cell tumor . All of the following are true except:
a. The lesion is more common in males
b. Ten percent are multiple
c. Three percent have malignant behavior
A, female
116
Myeloid sarcomas are most common in the? subtypes of AML.
M5a (monoblastic), M5b (monocytic), M4 (myelo-monocytic), and M2 (myeloblastic with maturation)
117
treat cutaneous leiomyosarcoma.
Mohs micrographic surgery—
118
bone marrow involvement with follicular lymphoma asymptomatic lymphadenopathy. bcl-2 positive
Systemic follicular lymphoma
119
treatment for systemic follicular lymphoma.
Rituximab anti-CD20 monoclonal antibody therapy
120
Treatment of papular acantholytic dyskeratosis
Ablative treatment—.
121
Primary cutaneous adenoid cystic carcinoma Rx
Oncologic evaluation followed by wide surgical excision.. A primary salivary gland or pulmonary ACC should be ruled out before making the diagnosis of PCACC. Perineural invasion is found in 76% of cases of PCACC and is related to an increased recurrence rate.5 A wide local excision with negative margins is therefore recommended.1,
122
What stage would you report in a patient with a 5.8-mm deep, ulcerated nodular melanoma, four microscopically positive nodes, and no sign of distant spread?
Stage 3C
What is the worse feature?
Stage4- distant mets , Stage 3-nodal mets( 3c >=4 nodes or macromets with ulcer), stage2- >=1mm plus ulcer OR 2-4mm +-ulcer
123
This stage of melanoma is thicker than 4.0 mm, but has not been found in the lymph nodes or other organs.
Stage IIc.
124
stage of melanoma involves one to three local lymph nodes only at the microscopic level, but there is no distant spread.
Stage IIIa
125
This stage of melanoma involves one to three local lymph nodes, and the nodes are enlarged because of the involvement, but there is no distant spread.
D. Stage IIIc—
126
most com-monly associated malignancies LyP
mycosis fungoides,
anaplastic large cell lymphoma,
Hodgkin’s disease.
127
Dfsp distant metastases do occur, hematogenousspread most commonly involves
the lung.
128
Eruptive melanocytic nevi develops from
Transplant-associated immunosuppression
129
Melanomas organ transplant associated with
Precursor nevi
130
characteristic dermoscopic feature eriptive melanocytic nevi
is a rim of peripheral brown globules representingpigmented nests of melanocytes,
131
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mortality?
Squamous cell carcinoma
melanoma
sebaceous cell carcinoma
basal cell
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Melanoma> sebaceous cell carcinoma>squa-mous cell carcinoma> basal cell carcinoma
