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AAD ETAS > neoplasms > Flashcards

neoplasms Flashcards

1
Q

ear SCC invading cartilage staging

A

T4

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2
Q

> 4 mm with ulceration melanoma

A

stage 2c

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3
Q

hundreds disseminated KA

A

grzybowski

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4
Q

adulthood larynx mucosa KA

A

gryzybowski

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5
Q

maple leaf structure

A

pBCC

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6
Q

p53 G1 cycle mutations

A

AK

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7
Q

periungual SCC HPV

A

HPV 16

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8
Q

Asian indians commonest skin ca

A

SCC

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9
Q

red chapped liplaser

A

CO2

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10
Q

SLN bx recommended for

A

intermediate thickness accurate staging

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11
Q

giant CMN melanoma risk

A

6%,

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12
Q

myotonic dystrophy aw

A

pilomatricomas,

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13
Q

AK incidence reduced by

A

lo-fat diet

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14
Q

HPV 6,11

A

genital wart

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15
Q

Lmyc amplification

A

MCC

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16
Q

intraoral melanoma location

A

hard palate

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17
Q

pseudorosettes trabecular variant

A

MCC

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18
Q

MCC margins head neck

A

3 cm

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19
Q

NSE ACTH CD44

A

MCC

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20
Q

MCC mets potential ?

A

Yes

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21
Q

syringotropic MF biopsy

A

punch

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22
Q

MM staging criteria

A

breslow ulceration

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23
Q

MM women site

A

legs

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24
Q

MM men site

A

back

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25
Q

spina bifida macrocephaly ododogenic cyst

A

gorlin

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26
Q

medulloblastoma

A

gorlin

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27
Q

poikilodermatous MF aw

A

LyP

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28
Q

imiquimod cytokines

A

IL1 5 6 8,

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29
Q

lowest recurrence AK site

A

mid forehead

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30
Q

cryo cure rate AK

A

99%,

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31
Q

celecoxib

A

UV chemopreventive

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32
Q

in MM p53 activate ___promotoe apoptosis inhibit ___

A

PUMA, bcl2

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33
Q

stage 4-MMnon visceral mets

A

better prognsosis

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34
Q

base nose UVR risk

A

cUVR

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35
Q

vimentin s100 HMB45

A

melanocytic

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36
Q

polyomavirus chromogranin NSE synaptotophysin ck20/8

A

MCC

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37
Q

pinkus BCC site

A

lumbosacral

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38
Q

SCC oral site commest

A

lateral tongue

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39
Q

epitheloid sarcoma sites

A

hands forearms

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40
Q

transplant? Risk skin ca

A

4x

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41
Q

risk in transplant in order

melanoma bcc scc mcc

A

SCC>bcc>melanoma> MCC

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42
Q

organ transplant SCC

A

x65

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43
Q

Melanoma leukoderma

A

mets dz

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44
Q

prolong survival st 3/4 melanoma

A

ipilumumab

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45
Q

ipilumumab cytokines

A

TNF IFN-A IL2

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46
Q

CD34+ F13a-ve

A

DFSP

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47
Q

cytogeneitc reciprocal translocation t(17:22)(q22;q13)

A

DFSP

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48
Q

monoclonal gene rearrangement in

A

CTCL

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49
Q

denileukin difitox

A

CTCL systemic Rx-

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50
Q

SCC cryo temp

A

-50 deg

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51
Q

1 mucinous ca location

A

eyelid

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52
Q

pseudodarier

A

multiple leiomyoma

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53
Q

multiple leiomyoma ca link

A

RCC

54
Q

SCC low risk location

A

chest

55
Q

Chloroma aw

A

leukemia

56
Q

SCC % recurrence excision

A

20%

57
Q

bazex vs Rombo

A

hypohidrosis present in bazex

58
Q

pagetoid reticulosis locaitons

A

hands feet,

59
Q

MAC location

A

periorbital nasolabial perioral

60
Q

CD31 CK CD34

A

angiosarcoma

61
Q

diptheria fusion toxin IL2 rceptor

A

denileukin difitox

62
Q

which B cell lymphoma express :
B-cell antigens (CD20, CD79a)+
absent t(14;18) translocation,
Bcl-2 -, Bcl-6 +

A

PCFCL

63
Q

which B cell lymphoma has Predilection for the head, neck,
and trunk
Elderly patients

A

PCFCL

“follicle is blackHEAD” vs “marginalized”

64
Q

which B cell lymphoma has Predilection for trunk and
upper extremities
Younger patients (median age,
55 years)

A

Marginal zone lymphoma

65
Q

The 5-year survival of PCFCL

A

favorable, with rates up to 95% in large studies.

66
Q

which B cell lymphoma express :
CD20, CD79a+
Bcl-2 + Bcl-6 -
CD10-

A

PMZL

67
Q

Bcl-2 + Bcl-6 -

A

PMZL ( does a 2+6- dance)

68
Q

bcl2 -, bcl6+

A

PCFCL

69
Q

which B cell lymphoma has poorer prognosis, 5-year survival rates of 50%

A

PCBCL-LT

70
Q

2 main negative prognostic factors of PCBCL-LT

A

Location on the leg and the presence of

multiple skin lesions a

71
Q

which B cell lymphoma expresses
Bcl-2+, MUM1/IRF4+
immunoglobulin M, and FOX-P1+

A

PCDLBCL-LT

72
Q

histology of B cell lymphomas - which have diffuse infiltrate but prognosis different!

A

PCDLBCL-LT( diffuse ) PCFCL

73
Q

RT alone or in combination with R-CHOP are
first-line treatment for solitary, localized, or
generalized disease

A

PCDLBCL-LT( diffuse

74
Q

A 56-year-old woman presented with a bluish-red 6-cm
nodule on the anterior aspect of her left shin. An incisional
biopsy specimen was obtained, and the histologic review
revealed a diffuse infiltrate of centroblasts and immunoblasts in confluent sheets.
2. Which of the following findings lends support to a
diagnosis with a more favorable prognosis?

A

Negative immunoglobulin M expression
diffuse infiltrate can be either PFCL or PDLPCDL BCL-LT
Strong
and widespread cytoplasmic immunoglobulin
M expression is characteristic of PCDLBCL-LT,whereas
PCFCL is negative for immunoglobulin M

75
Q

treatment of primary cutaneous follicle center lymphoma

Solitary/localized

A

Local radiotherapy and excision

76
Q

Vemurafenib has a relatively short timeto response and improves overall survival in patients with melanoma
harboring a ? mutation.

A

a BRAF V600E mutation.

77
Q

What Stage melanoma includes metastatic dis-ease in the regional lymph nodes, in-transit disease, or satellite metastases

A

Stage III melanoma

78
Q

IFNa Common contraindications:

A

atrial fibrillation; depression,
with history of psychiatric
hospitalization or suicidality;

79
Q

role of radiation as an adjuvant therapy for melanoma.

A

Adjuvant radiotherapy may be considered whenextracapsular extension is noted histologically inan effort to improve regional control

80
Q

development of in-transit metastases places a patient at stage ?

A

stage IIIC

81
Q

What may be considered for patients with in-transit metasta-ses localized to a single limb but too numerous to allow punch
excision or surgical resection

A

Isolated limb infusion or perfusion may beconsidered in effort to achieve locoregionalcontrol

82
Q

Presence of dysplastic nevi are associated with increased

A

melanoma risk in individuals

83
Q

Classic Spitz nevi size

A

<5-6 mm

84
Q

Classic Spitz nevi age

A

<10 years old

85
Q

Younger age is associated with ? behaving Spitz nevus

A

more likelybenign

86
Q

? mutations in acquired nevi, superficial spreading melanomas(SSM), and nodular melanomas

A

BRAF

87
Q

? mutations in Spitz nevi and Spitzoid lesions

A

HRAS

88
Q

?mutations in congenital nevi,

A

NRAS

89
Q

? alterations in acral and mucosal melanoma,

A

KIT

90
Q

GNAQ and GNA11 mutations in

A

ocular melanoma and blue nevi.

91
Q

In common Spitz nevus compared to mela-noma, Ki-67
HMB-45
S100-A6

A

In common Spitz nevus compared to mela-noma, Ki-67 is stained in fewer cells, HMB-45exhibits differential staining at certain le-sion depths, and S100-A6 is stained stronglyand diffusely

92
Q

metastatic potential in questionable Spitz tumors most recent
study indicates that the three most important criteria are

A

mitotic activity,

mitoses near the base, and inflammation

93
Q

?is usually recommended for adultswith Spitz nevi

A

Excision

94
Q

Common Spitz nevi in children may be managed

A

nonsurgically

95
Q

Atypical Spitz tumors may require ?to guide management

A

sentinel node biopsy

96
Q

approximate rate ofSLNB positivity would you expect to find for spitz tumors ?

A

40%

97
Q

Classical spitz Which of the following statements is true if the lymph node is positive?

A

possible that the surgeon will suggest a complete lymphadenectomy

98
Q

Organ transplant recipients have a ? increased risk for melanoma

A

three- to fivefold

99
Q

The risk of squamous cell carcinoma devel-opment increases with

A

time post transplant

100
Q

Patients with cutaneous T-cell lymphoma are susceptible to

A

S aureus infection

101
Q

What is the most common site of primary

extranodal lymphoma?

A

The most common primary site is the gastrointestinal

tract followed by the skin

102
Q

best treatment for indolent CBCLs

A

b. Surgery or radiation

103
Q

Which of the following lipid lowering agents may

impair renal function during cyclosporine treatmen

A

Fenofibrate

104
Q

Dfsp ,follow-up is recommended

A

Because risk of recurrence is

substantial,follow-up is recommended every 6 months for 5 years and then annually life.

105
Q

imatinib mesylate therapy, a molecular-targeted therapy that inhibitsmultiple tyrosine kinases, including the

A

PDGFb receptor tyrosine kinase that is overactive in DFSP.

106
Q

proliferating pilar cyst course

A

Slow growth with potential malignant

107
Q

Porokeratosis reason for increased propensity to cancer development is unknown, the candidate gene implicated in DSAP,

A

SART3, is a tumor rejection antigen, suggesting one possiblemechanism for neoplastic transformation

108
Q

Acquired ichthyosis commonest malignancy

A

Hodgkin disease

109
Q

Acquired icthyosis

Implicated medications

A

cimetidine
nicotinic acid
haloperidol
clofazimine

110
Q

most common site of metastasis is

A

the trunk

111
Q

Long-term risk EAI involves:

A

Squamous cell carcinoma

Merkel cell carcinoma

112
Q

Cutaneous involvement of internal malignancies occurs in what percentage of patients?

A

1% to 9%

113
Q

most common cause of cutaneous metastasis in men?

A

Bronchogenic carcinoma

114
Q

treatment leiomyoma multiple includes

A

Cold avoidance
Gabapentin
Intralesional botulinum toxin
Nifedipine

115
Q

Re granular cell tumor . All of the following are true except:

a. The lesion is more common in males
b. Ten percent are multiple
c. Three percent have malignant behavior

A

A, female

116
Q

Myeloid sarcomas are most common in the? subtypes of AML.

A

M5a (monoblastic), M5b (monocytic), M4 (myelo-monocytic), and M2 (myeloblastic with maturation)

117
Q

treat cutaneous leiomyosarcoma.

A

Mohs micrographic surgery—

118
Q

bone marrow involvement with follicular lymphoma asymptomatic lymphadenopathy. bcl-2 positive

A

Systemic follicular lymphoma

119
Q

treatment for systemic follicular lymphoma.

A

Rituximab anti-CD20 monoclonal antibody therapy

120
Q

Treatment of papular acantholytic dyskeratosis

A

Ablative treatment—.

121
Q

Primary cutaneous adenoid cystic carcinoma Rx

A

Oncologic evaluation followed by wide surgical excision.. A primary salivary gland or pulmonary ACC should be ruled out before making the diagnosis of PCACC. Perineural invasion is found in 76% of cases of PCACC and is related to an increased recurrence rate.5 A wide local excision with negative margins is therefore recommended.1,

122
Q

What stage would you report in a patient with a 5.8-mm deep, ulcerated nodular melanoma, four microscopically positive nodes, and no sign of distant spread?

A

Stage 3C
What is the worse feature?
Stage4- distant mets , Stage 3-nodal mets( 3c >=4 nodes or macromets with ulcer), stage2- >=1mm plus ulcer OR 2-4mm +-ulcer

123
Q

This stage of melanoma is thicker than 4.0 mm, but has not been found in the lymph nodes or other organs.

A

Stage IIc.

124
Q

stage of melanoma involves one to three local lymph nodes only at the microscopic level, but there is no distant spread.

A

Stage IIIa

125
Q

This stage of melanoma involves one to three local lymph nodes, and the nodes are enlarged because of the involvement, but there is no distant spread.

A

D. Stage IIIc—

126
Q

most com-monly associated malignancies LyP

A

mycosis fungoides,
anaplastic large cell lymphoma,
Hodgkin’s disease.

127
Q

Dfsp distant metastases do occur, hematogenousspread most commonly involves

A

the lung.

128
Q

Eruptive melanocytic nevi develops from

A

Transplant-associated immunosuppression

129
Q

Melanomas organ transplant associated with

A

Precursor nevi

130
Q

characteristic dermoscopic feature eriptive melanocytic nevi

A

is a rim of peripheral brown globules representingpigmented nests of melanocytes,

131
Q 
mortality?
Squamous cell carcinoma 
melanoma 
sebaceous cell carcinoma 
basal cell
A

Melanoma> sebaceous cell carcinoma>squa-mous cell carcinoma> basal cell carcinoma

AAD ETAS (12 decks)

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