pharmacology Flashcards
ear side effect of furosemide?
ototoxic- hearing loss
best HRT for migraine prone women?
patches as less fluctating hormones which can cause migraines
syx seretonin syndrome
confusion
agitation
myoclonus
sweating
fever
diarrhoea
when to withhold statin?
with clarithromycin
amiodarone and simvasstatin?
amiodarone increases SE of simvastatin
SE methyphenidate
reduced growth
decreased appetite
alopecia
tachycardia
hypertension
ciprofloxacin increase risk of?
tenon rupture eg achilles tenon
/tendonitis
clarithromycin and cardiac risk?
increase risk of cardiac events EG MI due to rupture existing plaques
how to wean off B blockers?
gadually over 2 weeks as sudden stops can cause rebound MIs
Jarish- Herxheimer reaction
syx
eg common after starting treatment for syshphillis -its breakdown of bacterial cell wall by abx
syx
fever, chills, tachycardia, myalgia
SE lithium?
hypernatraemia
confusion
tremors
vomiting
harm of longterm nitrofurantoin?
pulmonary fibrosis
anticoagulant of choice in pregnancy
heparin
antidepressant with worst discontinuation side effects?
least likely to cause discontinuation?
venlafaxine
shortest half life and proxetine
fluoxetine
SE carbamazepine?
leucopenia
agranulocytosis
thrombocytopenia
drugs prolong QT
citalopram
clarithromycin
mirtazapine SEs
15 mg starting dose
more sleepy
higher doses less sleepy
breastfeeding and contraception
PRE 6 WEEKS do not want combined OCP as reduces breast milk production
yellow fever contraindication
anaphylactic egg allergy
emergency contraceptive if had bariatric surgery
copper intrauterine device
antidepresssant to avoid with tamoxifen
fluoxetine reeduces efficacy
SE colchichine
D+V
thiazide diretic eg
indapamide
affect Na?
hyponatraemia
raynauds phenomenon
med which
- causes
- treats
- B blocker cauases
- nifedipine CA channel blocker helps treat = dilates vessels
best benzodiazapine to swap to reduce withdrawal from loraz?
diazepam
cause drug induced psoriasis?
B blockers commonly
risk with SGLT2 (eg dapagliflozin)
euglycaemic DKA can occur when dehydrated
- DKA syx, ketones but normal BM
common SE metformin
abdo pain and diarrhoea
order to treat folate and B12 deficiency
1) b12 first to avoid worsening neurological symptoms and precipitating subacute combined degeneration of cord
drugs to avoid with methotrexate ?
Trimethoprim and co-trimoxazole
risk of bone marrow aplasia (both anti folate meds)
Local anesthetic toxicity can be treated with
IV 20% lipid emulsion
Visual changes secondary to drugs
blue vision:
yellow-green vision:]
Viagra (‘the blue pill’)
digoxin
