Pharmacology

Question 1

What is the most important parameter to consider when prescribing beta lactam antibiotics?

Answer 1

Time above MIC (time dependent killing)
Also clindamycin, erythromycin, linezolid)

Question 2

What is MIC?

Answer 2

Primary measure of antibiotic activity - indicates potency.
Lowest concentration of an antibiotic that will completely inhibit the growth of a bacteria

Question 3

Which parameters are looked at when using aminoglycosides and fluoroquinolones?

Answer 3

Peak/MIC ratio

Question 4

Which antibiotics dosing revolves around 24h AUC/MIC ratio?

Answer 4

Azithromycin and vancomycin

Question 5

Which drug administration route will reduce drug bioavailability?

Answer 5

Oral - goes through first pass metabolism which reduces bioavailability
Can get around this by intravenous or prodrug administration

Question 6

How do you calculation bioavailability?

Answer 6

AUC oral/AUC IV x 100

Question 7

What antiepileptic medications can patients with Dravet not be given?

Answer 7

Sodium channel blockers due to abnormalities in the SCN1A gene (Sodium channel)
Lamotrigine
Phenytoin
Carbamazepine