Dermatology Flashcards
What is low Filaggrin in the skin indicative of?
Severe eczema
Also predisposed to asthma, rhinitis, food allergy
What steroid can you use on the face for eczema?
Hydrocortisone 1%
What is dupilumab and what is it used for?
Human monoclonal antibody against IL-4 and IL-13 targeting the Th2 pathway.
Used to treat eczema
What is upadacitinib and what is it used for?
Janus kinase inhibitor (JAK inhibitor)
Used in eczema
Why can you not use systemic steroids in psoriasis?
Risk of pustular flare on withdrawal which can be life threatening
Onset of a rash 1-6 weeks after initiation of an antibiotic
Eosinophilia, abnormal LFTS
Fever, malaise, pharyngitis, cervical
lymphadenopathy
DRESS
What is phytophotodermatosis?
Skin gets exposed to plants and then that area of skin gets exposed to the sun which then results in blistering and then followed by hyper pigmented area of skin
What is erythropoietic protoprophyria?
Erythropoietic protoporphyria (EPP) is an inherited cutaneous porphyria characterized by painful, nonblistering photosensitivity usually first noted in early childhood and occurring acutely after sunlight exposure but leaving little residual skin damage
What is congenital erythropoietic prophyria?
Painful blisters with scarring, hypertrichosis, red urine, stained teeth and anaemia
What is the inheritance pattern in incontinentia pigmenti?
X-linked dominant
What is the gene for incontinentia pigmenti?
IKBKG
What are the stages of incontinentia pigmenti?
- Vesicular stage
- Verrucous stage
- Hyperpigmented stage
- Atrophic stage
What other things are associated with incontinentia pigmenti?
Absent teeth
Eye abnormalities - strabismus, proliferative retinopathy
Neurological signs - seizures, intellectual impairment
Nail dystrophy
Alopecia
What is PHACES syndrome?
Posterior fossa brain abnormalities
Segmental Haemangioma of the head/neck
Arterial abnormalities
Coarctation of aorta
Eye abnormalities
Sternum abnormalities
Need MRA head and neck
ECHO and ophthalmology referral
Aspirin to reduce stroke risk and beta blockers
What do you see in Kasabach Meritte phenomenon?
- Rapidly expanding vascular tumour
- Consumptive coagulopathy
- Thrombocytopaenia
- Microangiopathic haemolytic anaemia
Reported with:
* Kaposiform haemangioendotheliomas
* Tufted angiomas