Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RACP Paediatrics Exam > Immunology > Flashcards

Immunology Flashcards

1
Q

What cell is associated with CD56?

A

NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which cells are associated with CD3?

A

T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which cells are associated with CD19?

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which deficiency can be implicated in X-linked agammaglobulinaemia?

A

Brutons tyrosine kinase deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which immunoglobulin makes up 80% of the bodies immunoglobulins?

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which immunoglobulin makes up the smallest portion of immunoglobulins in the body?

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which immunisation type doesn’t require T cell assistance?

A

Polysaccharide immunisations such as Pneumovax
Note: Prevnar is a T cell dependent conjugate polysaccharide immunisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the problem seen in X-linked HyperIgM syndrome and what infections are people with this condition most susceptible to?

A

CD40 ligand deficiency on T cells - IgM not able to isotype switch to other immunoglobulins
At risk of Fungal - PJP and recurrent bacterial infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the clinical features of SCID?

A

No tonsils, lymph nodes
Low IgG
Absent thymic shadow
Very low lymphocyte counts
No T cells (CD3, 4, 8), variably reduced B & NK cells
Defective T cell function (Absent proliferation to mitogens)
Specific features may discriminate SCID variants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which receptor do MHC1 (on all cells) respond to on T cells?

A

CD8+ (Cytotoxic T cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which receptor on T cells binds to MHC2 (only on APC)?

A

CD4+ (Helper T cells)
MHC2 - breaks antigen down intracellular then presents on surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which interleukins cause proliferation of T cells?

A

IL-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which immune subtype does someone with SCID who has No T cells or NK cells with presence of B cells have?

A

Common gamma chain X linked SCID or JAK3 SCID

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which immune subtype does someone with SCID who has No T cells or B cells with presence of NK cells have?

A

RAG1 or RAG2 or Artemis deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is tested for on NBST to check for SCID?

A

T Cell receptor excision circles (TREC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which interleukin stimulates bone marrow production?

A

IL-3

17
Q

Which interleukins stimulate the production of IgE?

A

IL-4 and IL-13 (note dupilumab is utilised in severe eczema to block IL-4 and IL-13)

18
Q

What is a positive skin prick test?

A

> 3mm above the saline result

19
Q

Is there an increased risk of food allergy in a child whose sibling is allergic to peanuts?

A

Yes - 1.5- 2.5x higher risk of food allergy

20
Q

If a child has a large cutaneous reaction to an insect bite what is the risk of having anaphylaxis to a subsequent insect bite?

A

<1%

21
Q

What is the risk of another anaphylactic reaction with a bee sting after having an anaphylactic reaction after being stung for the first time?

A

40-50%

22
Q

What condition are boys with X-linked chronic granulomatous disease at risk of?

A

Early onset IBD

23
Q

What is the issue with function in CGD?

A

Neutrophils are lacking the ability to use the NADPH oxidase enzyme to produce superoxide. Neutrophils can move to site of infection but can’t kill.
Test with DHR test

24
Q

What gene is associated with CGD?

A

CYBB (gp91hox sub unit)

25
Q

What are the 5 big organisms children with CGD are at risk of?

A

Staph.Aureus
Nocardi
Aspergillus
Burkholderia
Serratia Species

26
Q

What are the key features of leukocyte adhesion disease?

A

Delayed cord separation, omphalitis
WBC>15
Destructive gingivitis
Severe staph infection
No pus

27
Q

Which IL produces CRP?

A

IL-6

28
Q

What is the classical complement pathway activated by?

A

IgM and IgG

29
Q

Which complement subunit is related to SLE?

A

C1q
Classical complement deficiencies are strongly associated with autoimmune conditions

30
Q

Which complement subunit deficiency will cause severe pyogenic infections?

A

C3

31
Q

What part of the complement is associated with neisseria infections?

A

C5-9 MAC

32
Q

What is the target of alemtuzumab?

A

Lymphocytes and monocytes (CD52)

33
Q

What mutation is associated with Wiskott-Aldrich syndrome?

A

Missense mutation of Xp11.22
Encodes the WASp protein

34
Q
A

RACP Paediatrics Exam (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions