Pharmacology Flashcards
What would you see on lab investigations for a patient on prednisone?
hyperglycaemia, hypokalaemia, polycythaemia (erythropoietic effect)
Why is pethidine bad in renal failure?
Pethidine undergoes hydrolysis followed by partial conjugation with glucuronic acid in the liver to produce norpethidine. This compound has half the analgesic potency of pethidine but twice the central nervous system stimulation effects. Therefore, seizures and irritability are complications of the accumulation of norpethidine, particularly in the presence of renal impairment. Norpethidine has a half-life of 15–20 hours.
Why is pethidine bad in renal failure?
Pethidine undergoes hydrolysis followed by partial conjugation with glucuronic acid in the liver to produce norpethidine. This compound has half the analgesic potency of pethidine but twice the central nervous system stimulation effects. Therefore, seizures and irritability are complications of the accumulation of norpethidine, particularly in the presence of renal impairment. Norpethidine has a half-life of 15–20 hours.
What are beta-lactam antibiotics?
The most common beta-lactam antibiotics are the penicillins. Also in this category are the cephalosporins (ceftriaxone, cefaclor, cefuroxime), carbapenems (meropenem, imipenem), and monobactams (aztreonam).
