MSK and Skin

Question 1

What is the most common form of osteoporosis?

Answer 1

Involutional osteoporosis is the most common form of osteoporosis

Question 2

What is the pathology of osteoporosis?

Answer 2

Osteoporosis is caused by a relative excess of osteoclast function. Areas with a high trabecular bone content are affected.

Question 3

What is the pathology of Marfan’s syndrome?

Answer 3

Marfan syndrome is a genetic disorder affecting the connective tissue. Marfan syndrome is caused by a mutation in FBN1. This gene makes fibrillin, an important component of connective tissue. It is an autosomal dominant disorder.

Question 4

What is the pathology of osteogenesis imperfecta?

Answer 4

a mutation in type 1 collagen

Question 5

What does a mutation in type 2 collagen cause?

Answer 5

Achondrogenesis type 2 and hypochondrogenesis occur with a mutation in collagen type 2.

Question 6

What is genetically linked to fibrillin 2 mutations?

Answer 6

Congenital contractural arachnodactyly (CCA) has been genetically linked to fibrillin 2 mutations

Question 7

Where are osteomas most commonly found?

Answer 7

In the head and neck

Question 8

What are osteomas?

Answer 8

Osteomas are bosselated, round-to-oval sessile tumours that project from the subperiosteal surface of the cortex

Question 9

What is a chondroma?

Answer 9

Chondromas are usually solitary metaphyseal lesions of tubular bones; the favored sites are the short, tubular bones of the hands and feet.