What is the most common form of osteoporosis?
Involutional osteoporosis is the most common form of osteoporosis
What is the pathology of osteoporosis?
Osteoporosis is caused by a relative excess of osteoclast function. Areas with a high trabecular bone content are affected.
What is the pathology of Marfan’s syndrome?
Marfan syndrome is a genetic disorder affecting the connective tissue. Marfan syndrome is caused by a mutation in FBN1. This gene makes fibrillin, an important component of connective tissue. It is an autosomal dominant disorder.
What is the pathology of osteogenesis imperfecta?
a mutation in type 1 collagen
What does a mutation in type 2 collagen cause?
Achondrogenesis type 2 and hypochondrogenesis occur with a mutation in collagen type 2.
What is genetically linked to fibrillin 2 mutations?
Congenital contractural arachnodactyly (CCA) has been genetically linked to fibrillin 2 mutations
Where are osteomas most commonly found?
In the head and neck
What are osteomas?
Osteomas are bosselated, round-to-oval sessile tumours that project from the subperiosteal surface of the cortex
What is a chondroma?
Chondromas are usually solitary metaphyseal lesions of tubular bones; the favored sites are the short, tubular bones of the hands and feet.
