Pharmacologic Treatment of Parkinson Disease

Question 1

Levodopa/carbidopa

Answer 1

MOA: dopamine precursor plus dopa decarboxylase inhibitor; anorexia, nausea, psychosis, hallucinations, orthostatic hypotension, dyskinesia

Question 2

Trihexyphenidyl

Answer 2

MOA: anticholinergic; dry mouth, constipation, urinary retention, confusion, hallucinations, narrow-angle glaucoma

Question 3

Benztropine

Answer 3

anticholinergic; dry mouth, constipation, urinary retention, confusion, hallucinations, narrow-angle glaucoma

Question 4

Amantadine

Answer 4

NMDA antagonist; hallucinations, leg edema, livedo reticularis

Question 5

Selegiline

Answer 5

MAO-B inhibitor; agitation, insomnia, hallucinations

Question 6

Rasagiline

Answer 6

MAO-B inhibitor; increased dyskinesias, postural hypotension, headaches

Question 7

Bromocriptine

Answer 7

dopamine agonist; nausea, orthostatic hypotension, psychosis, hallucinations, dyskinesea

Question 8

Pergolide

Answer 8

dopamine agonist; nausea, orthostatic hypotension, psychosis, hallucinations, dyskinesea

Question 9

Pramipexole

Answer 9

dopamine agonist; nausea, orthostatic hypotension, psychosis, hallucinations, dyskinesea

Question 10

Ropinirole

Answer 10

dopamine agonist; nausea, orthostatic hypotension, psychosis, hallucinations, dyskinesea

Question 11

Rotigotine

Answer 11

Dopamine agonist; nausea, application site reaction, somnolence, dizziness, headaches

Question 12

Tolcapone

Answer 12

COMT inhibitor; nausea, vomiting, insomnia, orthostatic hypotensions, confusion, dyskinesia

Question 13

Entacapone

Answer 13

COMT inhibitor; nausea, vomiting, insomnia, orthostatic hypotensions, confusion, dyskinesia