Antiepileptic Drugs

Question 1

Phenytoin (Dilantin)

Answer 1

Na channel; partial; gingival hyperplasia, coarsening of facial features, ataxia

Question 2

Carbamazepine (Tegretol)

Answer 2

Na channel; partial; hyponatremia, agranulocytosis, diplopia

Question 3

Valproic Acid (Depakote)

Answer 3

Na channel, GABA receptor; partial, generalized; GI symptoms, weight gain, hair loss, hepatatoxicity, thrombocytopenia

Question 4

Phenobarbital

Answer 4

GABA receptor; partial, generalized; sedation

Question 5

Ethosuximide (Zarontin)

Answer 5

T-type Ca channel; absence; GI symptoms

Question 6

Gabapentin (Neurontin)

Answer 6

Unknown, possible voltage-gated Ca channel; partial; sedation, ataxia

Question 7

Lamotrigine (Lamictal)

Answer 7

Na channel, glutamate receptor; partial, generalized; rash, SJS

Question 8

Topiramate (Topamax)

Answer 8

Na channel, GABA activity; partial, generalized; word-finding difficulty, renal stones, weight loss

Question 9

Tiagabine (Gabitril)

Answer 9

GABA reuptake; partial; sedation

Question 10

Levatiracetam (Keppra)

Answer 10

Unknown, possibly synaptic vesicles; partial, generalized; insomnia, anxiety, irritability

Question 11

Oxcarbazepine (Trileptal)

Answer 11

Na channel; partial; sedation, hyponatremia

Question 12

Zonisamide (Zonagran)

Answer 12

Unknown; partial, generalized; sedation, renal stones, weight loss