Pharmacokinetics and dynamics

Question 1

What is pharmacokinetics

Answer 1

What happens to the drug in the body (ADME)

Question 2

What are the 4 mechanisms of pharmacokinetics

Answer 2

Administration
Distribution
Metabolism
Excretion

Question 3

What factors play a part in drug administration

Answer 3

Route and entry into body

Bioavailability

Question 4

What is bioavailability

Answer 4

How fast and to what extent the drug reaches systemic circulation
(IV= 100%)

Question 5

How are drugs distributed in the body

Answer 5

In the plasma according to chemical properties and size

Question 6

How are drugs metabolised in the body

Answer 6

Kidney and liver
Kidney = small water soluble drugs
Liver = hydrophobic molecules

Question 7

What is metabolism classified by

Answer 7

Rate and phase
Rate (Does action increase with time or stay constant)
Phase 1 - Mild hydrophobic increase by microsomal enzymes w/ OH group
Phase 2 - Major hydrophobic increase by Conjugation

Question 8

How are drugs excreted

Answer 8

Urine by kidney filter and faeces

Question 9

What is Pharmacodynamics

Answer 9

The effect of drug on the body

Question 10

Phase 1 metabolism increases hydrophobilicity by….

Answer 10

Adding OH group

Question 11

Phase 2 metabolism increases hydrophobilicity by….

Answer 11

Conjugation