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ICS > Drug Targets > Flashcards

Drug Targets Flashcards

1
Q

What are the routes of drug administration

A 
Enteral (Oral)
Parenteral (Non GIT, IM, IV, SC)
Inhaled ICS
Topical cream
Rectal
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2
Q

What is the most common drug target

A

G Protein Coupled Receptor

  • Agonist
  • Antagonist
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3
Q

What is the difference in affinity and efficacy between antagonist and agonist drugs

A 
Agonist = Full affinity and efficacy
Anatgonist = Full affinity and ZERO Efficacy
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4
Q

What is affinity

A

How well it binds

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5
Q

What is efficacy

A

How well the receptor activates

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6
Q

What is Potency

A

How much drug needed to elicit a response in the body

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7
Q

What is the difference in potency and efficacy between competitive and non competitive antagonists

A

Competitive = decrease potency but same efficacy

Non Comp = Decrease potency and efficacy

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8
Q

What are allosteric modulators

A

Change normal ligand binding

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9
Q

What is a non selective beta blocker

A

Propanolol

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10
Q

What is a selective beta blocker

A

Atenolol/Bisoprolol

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11
Q

What is a non selective beta agonist

A

Isoprenaline (Increases contractility and vasoconstriction)

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12
Q

What is a selective Beta2 agonist

A

SAB2A (Bronchodilation)

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13
Q

What is an NSAID

A

COX-1 Inhibitor (Prevent arachidonic acid becoming prostaglandin)
SE = Ulcers

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14
Q

What is an ACE-I

A

Inhibits Angiotensin 1 into 2

SE =Hyperkalemia, dry cough and teratogenic

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15
Q

What is a PPI

A

Irreversible inhibition of H-K ATPase pump to lower gastric pH

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16
Q

What is a loop diuretic

A

Inhibit NKCC2 Symporter in ascending loop of henle

17
Q

What is a thiazide diuretic

A

Inhibit NaCl co transporter in DCT

18
Q

What is Spiranolactone

A

K sparing aldosterone inhibitor

19
Q

What is a CCB

A

Decreases vasoconstriction and contractility by inhibiting Calcium Influx

20
Q

How does Lidocaine (Anaethesia) work

A

Block Na voltage gated channels = low sodium influx = no ABP

21
Q

What is meant by a specific drug

A

Acts on certain target

22
Q

What is meant by selective drugs

A

Acts on target subtype (general)

ICS (17 decks)

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