Drug Targets Flashcards
What are the routes of drug administration
Enteral (Oral) Parenteral (Non GIT, IM, IV, SC) Inhaled ICS Topical cream Rectal
What is the most common drug target
G Protein Coupled Receptor
- Agonist
- Antagonist
What is the difference in affinity and efficacy between antagonist and agonist drugs
Agonist = Full affinity and efficacy Anatgonist = Full affinity and ZERO Efficacy
What is affinity
How well it binds
What is efficacy
How well the receptor activates
What is Potency
How much drug needed to elicit a response in the body
What is the difference in potency and efficacy between competitive and non competitive antagonists
Competitive = decrease potency but same efficacy
Non Comp = Decrease potency and efficacy
What are allosteric modulators
Change normal ligand binding
What is a non selective beta blocker
Propanolol
What is a selective beta blocker
Atenolol/Bisoprolol
What is a non selective beta agonist
Isoprenaline (Increases contractility and vasoconstriction)
What is a selective Beta2 agonist
SAB2A (Bronchodilation)
What is an NSAID
COX-1 Inhibitor (Prevent arachidonic acid becoming prostaglandin)
SE = Ulcers
What is an ACE-I
Inhibits Angiotensin 1 into 2
SE =Hyperkalemia, dry cough and teratogenic
What is a PPI
Irreversible inhibition of H-K ATPase pump to lower gastric pH
What is a loop diuretic
Inhibit NKCC2 Symporter in ascending loop of henle
What is a thiazide diuretic
Inhibit NaCl co transporter in DCT
What is Spiranolactone
K sparing aldosterone inhibitor
What is a CCB
Decreases vasoconstriction and contractility by inhibiting Calcium Influx
How does Lidocaine (Anaethesia) work
Block Na voltage gated channels = low sodium influx = no ABP
What is meant by a specific drug
Acts on certain target
What is meant by selective drugs
Acts on target subtype (general)
