Adaptive Immunity Flashcards
Describe adaptive immunity
Specific Slow Needs activation Has memory Antibody mediated killing by T and B cell
Where do T cells mature
Thymus
In the thymus, Why is Thymic Tolerance needed
Choose the best T cells
What are the conditions of thymic tolerance
Positive selection (Do T cells recognise self MHC)
Negative selection (Do T cells produce immune response against itself) Choose against
Allocation
-Tc if CD8+ interaction on MHC1
-Th if CD4+ Interaction on MHC2
What happens if T cell interacts w/ CD8+
Perforin secretion by Granzyme B
FasL expression to activate caspases
What happens if T cell interacts w/ CD4+
IFNY to activate NK Cells and macrophages (Innate)
IL4 to activate B cells into Plasma cells (Acquired)
What are the two types of TH cells produced w/ CD4+ Interaction
TH1 =Release IFNY
TH2=Release IL4
How are B cells activated
TH2 Activation = APC binding and MHC2 interaction
TH2 Releases
-IL4 for B cell proliferation (Clonal expansion)
-IL5 for B cell differentiation into plasma cell -> Ig Abx
What is the difference between IL4 and IL5 Release by B cells
IL4 = Proliferation (Clonal expansion) IL5 = Differentiation into plasma cell and antibodies
What receptors do B cells have
CD19 and CD20
How can B cells produce a response against NON specific pathogens
Somatic Hypermutation and Class switching by Cysteine Deamilase
What is somatic hypermutation
Poin mutation in Ig as evolutionary measure
What is Class switching
Mutate Ig into another isomer
What promotes class switching to IgA
IL4
What promotes class switching to IgE
IL5
