Pharmacokinetics 4

Question 1

Zero Order Reaction Outline

Answer 1

Drug conc changes constantly with respect to time. Irrespective of starting conc. Constant amount of drug is eliminated per time. Half Life depends on initial conc of drug

Question 2

First Order Reaction Outline

Answer 2

Drug conc changes with respect to time with relation to amount of drug present (1st order rate constant). Constant fraction of drug id eliminated per time (as drug conc decreases elimination rate slows). Half Life is constant

Question 3

Zero Order Reaction on graph with linear units (rectangular coordinates)

Answer 3

Straight line

Question 4

1st order reaction on graph with linear units (rectangular coordinates)

Answer 4

Curved line

Question 5

0 order reaction on a graph with logarithmic conc

Answer 5

Curved line

Question 6

1st order reaction on a graph with logarithmic conc

Answer 6

Straight line

Question 7

Compartment Def

Answer 7

Sum of all tissues that drug distributes at approximately the same rate. Not physiologically important

Question 8

Single Compartment Model Assumptions

Answer 8

Drug in blood is at rapid equilibrium with drug in tissues, drug is mixed instantaneously in blood/plasma and drug elimination follows first order kinetics. Results in instantaneous distribution all over body

Question 9

2 Compartment models

Answer 9

Drug penetrates some tissues faster then others. Compartment 1/ central compartment = rapidly perfused tissues. Compartment 2/peripheral compartment = slowly perfused tissues. 2 phases of distribution before body reaches equilibrium

Question 10

One compartment model graph

Answer 10

slope remains relatively consistent. begins with a slow decline

Question 11

2 compartment model graph

Answer 11

Slope changes between distribution and elimination phases. Slope starts steep (big drop) and then begins to level out

Question 12

Relationship between efficacy, half life and K

Answer 12

more efficient = shorter half life = larger k