Cholinergic Signaling

Question 1

Only location of receptors

Answer 1

nicotinic

Question 2

Parasympathetic neurons

Answer 2

presynaptic neuron is long produces Acetylcholine. Postsynaptic neuron is short and produces acetylcholine. Cholinergic receptors on effector organ

Question 3

Parasympathomimetic Outline

Answer 3

Muscarinic agonists. cholinergic. Mimic acetylcholine

Question 4

Parasympatholytic Outline

Answer 4

Muscarinic antagonist. Anti-cholinergic

Question 5

Sympathomimetic Outline

Answer 5

Adrenergic agonist. Adregenric. mimics norepinephrine

Question 6

Cholinergic receptors

Answer 6

Muscarinic (M1-M5, slow, effector organs) and Nicotinic (in brain, nAchR, fast, signal relays)

Question 7

How does Ach be inactivated

Answer 7

hydrolysed by ubiquitous aetycholinterase

Question 8

Parasympathetic response

Answer 8

Rest-digest. Increases digestive and urinary function

Question 9

M1 Receptor Outline

Answer 9

Increase IP3, and diglyceride, causes depolarisation. CNS excitation, GIT secretions and GIT motility

Question 10

M2 Receptor Outline

Answer 10

Decrease cAMP. Decrease cardiac contractions

Question 11

M3 Receptor Outline

Answer 11

Increase IP3 and increase free calcium. Increases exocrine gland secretion