Pharmacokinetics

Question 1

What is pharmacokinetics?

Answer 1

Bodys effects on the drugs, concerns how a drug gains access to the plasma, if it stays in the plasma or prefers to distribute elsewhere, metabolism an dexcreton

Question 2

Are hydrophobic or hydrophilic drugs absorbed better

Answer 2

Hydrophobic (lipid soluble)

Question 3

What is phase I of biotransformation?

Answer 3

Reduction or hydrolysis of the drug but most commonly oxidation.
Yields a polar, water-soluble metabolite that is often still active.
Many of the products in this phase can also become substrates for phase II

Question 4

What is phase II of biotransformation?

Answer 4

Adding hydrophilic groups to the original molecule, a toxic intermediate or non-toxic metabolite formed in phase I that requires further transformation to increase its polarity.

Question 5

What is the most common method of phase II

Answer 5

Glucuronidation

Question 6

What is phase III of biotransformation?

Answer 6

Active transport of the compound into urinary or HPB system to facilitate elimination