Cytochrome P450 system Flashcards
What cytochrome shows the largest phenotypic variation?
CYP2D6
Which cytochrome is involved in the metabolism of clozapine
CYP1A2
What induces CYP1A2
Tobacco
What inhibits CYP1A2
Grapefruit juice
What does grapefruit juice inhibit?
CYP3A4
CYP1A2
What are the substrates of CYP1A2
Clozapine
Olanzapine
Asenapine
Agomelatine
Melatonin
What inhibits CYP1A2
Fluvoxamine
Grapefruit juie
What induces CYP1A2
Barbiturates
Tobacco
What are the substrates of CYP2D6
Amphetamines
Atomoxetine
Aripiprazole
Clomipramine
Fluoxetine*
Olanzapine
Risperidone
Mianserin
Imipramine
Venlafaxine
Zuclopenthixol
What are inhibitors of CYP2D6
Fluoxetine
Paroxetine
Bupropion
Asenapine
Amitriptyline
What are the substrates of CYP3A4
Aripiprazole
Clonazepam
Donepazil
Fentanyl
Methadone
Mirtazapine
Quetiapine
Zopiclone
What are the inhibitors of CYP3A4
Fluoxetine
Paroxetine
What are the inducers of CYP3A4
Carbamazepine
Phenobarbital
Phenytoin
St John’s Wort
Which cytochrome exhibits genetic polymorphism?
CYP2D6
What is the most common cytochrome
CYP3A4
What happens if something induces the system?
Increases activity of enzymes so the drug is metabolised faster and is less effective
What does it mean if something inhibits the system?
Reduces activity of enzymes so leads to increased levels of the drugs and can lead to toxicity or more severe side effects
