Half-life and drug metabolism Flashcards
How long does it take for a drug to reach steady state levels ?
5 half lives
What is the steady state?
When the amount of drug being eliminated from the body is the same as the amount being administered
How long does lithium take to reach steady state?
4-5 days
How long does aripiprazole take to reach steady state?
14-16 days
How long does carbamazepine take to reach steady state?
14 days
How long does olanzapine take to reach steady state ?
7 days
How long does risperidone depot take to reach steady state?
6-8 weeks
How long does paliperidone depot take to reach steady state ?
2 months
How many half lives does it take for a drug to be 97% eliminated?
5
How long do most drugs take to reach steady state?
2-3 days
What is zero order kinetics?
Where the plasma concentration of a drug decreases at a constant rate despite the concentration of the drug
What is first order kinetics?
Where drug elimination is at a proportional rate to the amount of drug in the body
