Pharmacogenetics Flashcards
1
Q
What are the four genotypes for metabolism?
A
UltraRapid: Substancially increased metabolic activity
Extensive: Normal
Intermediate: Reduced
Poor: Little to no functional activity
2
Q
Differentiate Prodrug vs active drug.
A
Prodrug: Inactive until they are metabolized
Active drugs: Inactivated during metabolism
3
Q
Which Cytochrome P450 is most studied and has high involvement in many medications?
A
- Debrisoquine hydroxylase or CYP2D6
4
Q
What is the 2nd most studied Cytochrome p450? What drugs are they involved in?
A
CYP2C19
- Proton Pump Inhibitor
- Antidepressants
5
Q
What drugs and affects are associated with CYP2C9?
A
- Medications with narrow therapeutic windows such as Warfarin and Tolbutamide
- Vitamin K epoxide reductase complex subunit 1 is responsible for pharmacodynamics of Warfarin
6
Q
What is the importance of TPMT in drug metabolism?
A
- Thiopurine methyltransferase
- Regulates balance between cytotoxic thiguanine nucleotide and inactive metabolite in hematopoietic cells
- ** 6-MP Metabolism
- ** Azothioprine metabolism
