Amino Acid Metabolism Flashcards
What are the Essential AAs?
PVT TIM HALL
How are amino group amino acids removed?
Urea Cycle
Keteogenic AAs are broken down to…
Acetyl CoA or Acetoacyl CoA
Glycogenin AAs are broken down to…
- Pyruvate
- 3-PG
- OAA
- a-KG
- Succinyl CoA
- Fumarate
What is Pyridoxal phosphate?
Vitamin B derivative acts as CoEnzyme for transamination reactions
What is the clinical significance of AST/ALT?
- Both are enzymes in transamination rxns
- Released into blood in Hepatic disease
- Diagnostic marker
Which organ mainly operates urea cycle?
Liver
How does NH3 affect pH?
Takes up H+ —> Alkalosis
What happens to glutamine After it reaches liver?
- Converted to glutamate and ammonia
- Ammonia enter urea cycle
What are the possible fates of glutamate?
- Urea
- Polyamine
- Glutathione
- GABA
- aKG (Glutamate DH)
- Glutamine (Glutamine Synthetase)
Describe the synthesis of Carbachol Phosphate.
NH4+ + HCO3- —> Carbomoylphosphate
- Uses 2 ATP
- CSP-I enzyme
- CSPI is in Mt and is allosteric regulated by N-Acetyl glutamate
What is normal BUN?
BUN (Blood Urea Nitrogen) is 10-20 mg/dL normally
What is the Cory Cycle, and it’s significance?
- Glucose-Alanine cycle btwn Muscle and Liver
- Muscle produces Alanine —> Liver
- Liver Uses Alanine and a-KG to produce Pyruvate and glutamate
- Pyruvate made into glucose in liver
What are the main functions of serotonin?
- Regulation of Temp and BP
- Vasoconstrictor and smooth muscle contraction
What is a Phechromocytoma?
Tumors of chromaffin tissues:
overproduction of catecholamines,
resulting in hypertension.
What is the pathology of Albinism?
- Tyrosinase deficiency leading to melanin deficiency
- Skin susceptible to sun damage
What are normal Blood creative levels?
<1.5 mg/dL
What is the role of Glutathione?
- Maintains protein thiol groups in their reduced state.
* In liver detoxifies xenobiotics (drugs, food additives etc).