Cytochromes Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Where is CYP450 located in smooth er and mt membrane?

A

sER:

  • Liver
  • Lung
  • Intestine
  • Brain
  • Skin

Mt:

  • Kidney
  • adrenals
  • Testis
  • Ovary
  • Placenta
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What kind of reaction is used by CYP450 for metabolism?

A

Hydroxylation

  • Uses NADPH, O2, and H+
  • Produces water and hydroxyl group on substrate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are common substrates of CYP450?

A
  • Long chain FA
  • steroids
  • Bile salts
  • Vit D
  • Heme
  • Pesticides
  • Herbicides (Defoliants)
  • Aromatic hydrocarbons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the clinical significance of Arachidonic Acid and CYP450?

A

CYP450 breaks down Arachidonic Acid

Arachidonic Acid used for:

  • Prostaglandins
  • Thrombaxanes
  • Prostacyclins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is a desmolase?

A

Sidechain cleavage enzyme used in cholesterol breakdown via CYP450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Define Prodrug.

A

The true therapeutic agent is generated by the patients metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly