Pharmacodynamics Flashcards
Define pharmacodynamics
Study of what drugs do to the body
Pharmacokinetics is
Pharmacodynamics is
A drug is a xenobiotic that induces an effect typically by interacting with an endogenous target molecule, also called a _____
Receptor
The ____ can be an enzyme, nucleic acid, or a special membrane brown protein
Receptor
A large class of drug receptors are ______ _____, a molecule produced by the body (endogenous). Examples include ligand gated ion channels, G protein coupled receptors
Physiological receptors
The second largest class of drug targets are _____. Example is penicillin, ACE Inhibitors
Enzymes
The third major class of drug receptors are _____.
Nucleic acids
Drug dose response graph. The drug concentration is on the X axis and a _____ on the Y axis
Biological effect
Fischer projection is a ___ and ____ model of thinking about enzyme and substrate interaction. This model has limitations
Lock and key
_____ is the equilibrium dissociation constant of a drug-receptor complex. ______ is the reciprocal of kD. If affinity is high, the dissociation constant will be low.
kD
Affinity
Low affinity requires a ____ concentration of molecules
Higher
The _____ is the free drug concentration at which half of the receptors are drug bound
KD (similar to Km)
Different drugs may possess distinct _____ for a common target (receptor)
Potencies
Drug A is more potent than drug B. It takes less concentration of drug A to reach the same effect
A lower ED50 of a drug means the _____ the potency.
Higher