pharma pt 2 Flashcards
indications adrenaline
anaphylaxis + cardiac arrest
dose adrenaline anaphylaxis and cardiac arrest
anaphlyaxis = 500mcg // cardiac arrest = 1g
effects of adrenaline
vasoconstriction in skin –> narrow pulse // vasodilation in skeletal muscles // inhibits insulin
mechanism flecainide
slows AP by blocking Na channel –> wide QRS + prolonged PR
indications flecainide
AF // SVT eg WPW
contraindications flecainide
post MI, HF, AV block, flutter
SE flecainide
negatively inotropic (weaken heart) // bradycardia // arrhythmia // oral paraesthesia // vision
mechanism digoxin
decreased AV node conduction // inhibits NaKATPase (increases force of heart)
monitoring digoxin
only in toxicity // measure within 8-12hrs last dose
levels indication digoxin toxicity
1.5-3
features digoxin toxicity
anorexia, confused, yellow-green vision // arrhythmia // gynaecomastia
RF digoxin toxicity
hypokalamia // renal failure // MI // hypo- // drugs
what meds increase risk of digoxin toxicity
amiodarone, verapamil, diltiazem, ciclosporin // hypokalaemmic drugs eg thiazides, loops
mx digoxin toxicity
digibind, correct arrhythmia, monitor K
examples alpha blockers
doxazosin + tamsulosin
SE alpha blocker
postural hypotension // drowsy // SOB // cough
examples K sparing diuretics
amiloride + spironolactone
when do K sparing diuretics have to be given with caution
ACEi –> hyperK
indications spironolactone
ascites // HF // Conns // nephrotic syndrome // resistant HTN
features BB overdose
bradycardia, hypotension, HF, syncope
mx BB overdose
atropine // glucagon
contraindications diclofenax
IHD, PAD, cerebrovascular disease, congestive HG
monitoring statin
LFT at baseline, 3 month, 12 months
