Pharma Halo-halo, CNS Flashcards
Rivastigmine class
Indirect-acting cholinomimetics
Acethylcholinesterase inhibtor
Classmates of rivastigmine
Dan (Donepezil)
Gayle (Galantamine)
Tucker (Tacrine)
Remarks on rivastigmine
Available as transdermal patch 📌
Remarks on donepezil
Combined with memantine (NMDA antagonist) for Alzheimer’s dementia
Bentropine moa
Muscarinic antagonist (non-selective)
Classmates of benztropine
Biperiden
Trihexyphenidyl
Antiviral used for parkinsonism
Amantadine
Remarks on amantadine
Prevents uncoating by binding to M2 proton channels
For influenza A only
May cause livido reticularis, crebellar dysfunction
What drugs may cause livido reticularis
A man reads FHM and GQ Amantadine Hydroxyurea Minocycline GEmcitabine Quinidine
Pathologic hallmark of PD
Loss of dopaminergic neurons of the substantia nigra pars compacta, with appearance of intracellular inclusions LEWY BODIES (containe a-synuclein) 🔥
Remarks on Levodopa-Carbidopa
Carbidopa: suicide to dopa decarboxylase
Hypertensive crisis occurs when used with MAOi
Ergot dopamine agonists
Bromocriptine Pergolide (cardiac fibrosis) Cabergoline Piribedil *valvular and lung fibrosis
S/e of bromocriptine
Erythromelalgia (burning pain and warmth and redness of extremities)
Pulmonary infiltrate
Drugs that cause pulmonary fibrosis
Bromocriptine Bleomycin Busulfan Amiodarone Nitrofurantoin Methotrexate
Non-ergot dopamine agonists
Pramipexole
Ropinirole
For restless leg syndrome
Remarks on pramipexole
Compulsive gambling Hypersexuality Overeating Sleep tendencies *impulse control disorders are attributed to the activation of D2/D3 receptors in the mesolimbic pathways of the brain
Opioid dopamine agonist
Apomorphine
Rabbit syndrome
Perioral tremor
Tx: benztropine
Mao B inhibitors
Selegiline
Rasagiline
Remarks on Mao B inhibitors
If used with meperidine, causes agitation, delirium and death
Serotonin syndrome occurs when used with SSRI, TCA, meperedine
No Cheese effect (hypertensive crisis with ingestion of tyramine rich food)
COMT inhiitor
Catechol-O-methyltransferase inhibitors
Entacapone (peripheral only)
Tolcapone (peri, cns)
Remarks on COMT inhibitors
Orange urine
Hepatotoxicity (tolcapone)
Rhabdomyolysis
Another classmate of benztropine
Procyclidine
Drugs that cause rhabdomyolysis
Tolcapone
Entecapone
Statin/fibrate 📌
