Endocrine Drugs

Question 1

Teriparatide

Answer 1

Recombinant parathyroid hormone

Question 2

Alendronate

Answer 2

Bisphoshonates
*strengthens hydroxyappatitie of the bones
*inhibition of formatiotn of farnesyl pyrophosphate (which is important for survival of osteoclasts
S/E: osteonecrosis of the jaw

Question 3

Denosumab

Answer 3

RANKL inhibitor

S/e: infections

Question 4

Cinacalcet

Answer 4

Calcium sensing receptor agonist, telling it na okay na yung calcium, leading to decreased PTH
*used in hyperPTH

Question 5

Romosozumab

Answer 5

Sclerostin inhibitor
Inhibits signal for osteoclast to differentiate
It’s the only non-hormonal tx with known adverse cardiac events

Question 6

RANK VS RANKL vs osteoprotegenin

Answer 6

RANKL: found in osteoBlasts
RANK: found on proosteoclasts
Osteoprotegerin (OPG): produced by osteoblasts and acts as a decoy for RANKL

Question 7

Sevelamer

Answer 7

Phosphate binding resin
*prevents absorption of dietary phosphate
*Used in hyperPTH in CKD
*used in hypoPTH
*used in vitamin 
D intoxication

Question 8

Raloxifene

Answer 8

SERM: interact selectively with estrogen receptors leading to inhibition of bone resorption without stimulating breast or endometrial hyperplasia

Question 9

PTH

Answer 9

MOA: Increases in cAMP

• at high doses, net effect is increased bone resorption, hypercalcemia, and hyperphosphatemia 📌
• at low intermittend doses, PTH produces a net increase in bone FORMATION