Pharma 3.4

Question 1

Tyrosine kinase inhibitor

Answer 1

Imatinib

• treatment of CML
• S/E: fluid retention, multiple drug interactions

Question 2

Active vs cells expressing her-2/neu

Answer 2

Trastuzumab

-treatment of metastatic breast and gastric cancer

Question 3

Inhibits VEGF

Answer 3

Bevacizumab

Tx of metastatic cancers

Question 4

Treatment of APML

Answer 4

All trans retinoic acid
(ATRA)
Differentiation therapy

Question 5

Used for chronic severe lead poisoning, acute symptomatic cses

Answer 5

EDTA

S/E: hypocalcemia, renal toxicity

Question 6

Remarks on arsenic poisoning

Answer 6

Rice water stools
Garlicky breath
Mee’s lines
Raindrop pigmentation
Milk and roses complexion

Question 7

Remarks on organic mercury poisoning

Answer 7

Minamata disease

Cerebral palsy, deafness, blindness, mental retardatiotn

Question 8

Remarks on iron poisoning

Answer 8

Severe GI necrosis
Hemosiderosis
Restrictive cardiomyopathy

Question 9

Tx of acute iron poisoning, hemochromatosis

Answer 9

Deferoxamine

Deferasirox (oral)

Question 10

Sunflower cataracts

Answer 10

Copper poisoning
-hepatotoxicity
-Kayser-Fleischer rings
-penicillamine
>>drug-induced lupus