Pharma Dr. Mariko lect 11

Question 1

Glutamate receptors

give 2 names

Answer 1

AMPA receptor

NMDA receptor

Question 2

AMPA receptors

1. classification
2. properties

Answer 2

1. ligand gated ion channels

2. Na permeable

Question 3

NMDA receptors

1. classification
2. properties

Answer 3

1. ligand gated ion channels.

2. Ca permeable and voltage dependent due to Mg block.

Question 4

AMPA receptors

1. function
2. localization

Answer 4

1. activated by glutamate
   mediates excitatory
   neurotransmission
2. entire CNS

Question 5

NMDA receptors

3. function
4. localization

Answer 5

3. activation requires
   - glutamate and membrane depolarisation
   - mediates synaptic plasticity

Question 6

Drugs associated with AMPA receptors

Answer 6

Not in clinical use

Question 7

NMDA receptors
name
mechanism
application

Answer 7

Ketamine
block at channel pore
anaesthetics

Question 8

central nerve medicine targets

Answer 8

glutamate receptors like AMPA or NMDA receptors