Pharma Dr, Mariko lec 14 Flashcards
Para-sympathomimetic agents and para-sympatholytic agents target…
muscarinic acetylcholine receptors
Muscarinic acetylcholine receptor
classification
localization
G protein-coupled receptor GPCR
target organs of postganglionic para-sympathetic fibers
Muscarinic acetylcholine receptor
function
cardiac: inhibition effects
glandular/smooth muscle: excitatory effects
Drugs that facilitate para-sympathetic nervous system actions
mechanism
activate muscarinic receptors
inhibit acetylcholinesterase
Drugs that facilitate para-sympathetic nervous system actions
application
reduce blood pressure
and
facilitate function of gastrointestinal tract
Drugs that block para-sympathetic nervous system actions
mechanism
block muscarinic receptors
Drugs that block para-sympathetic nervous system actions
application
-reduce secretion