Pharm- Tb

Question 1

Isoniazid- Indications

Answer 1

First line tx for Tb

Question 2

Isoniazid- MOA

Answer 2

Inhibits synthesis of mycelia acid

- Bacteracidal & static

Question 3

Isoniazid- AE

Answer 3

• Peripheral neuritis- hand and feet paresthesias
• Supplement with Vitamin B6
• Hepatoxicity

Question 4

Isoniazid- Monitoring

Answer 4

LFTs & opthal exams

Question 5

Rifampin- Indications

Answer 5

First line tx for Tb- in conjunction with isoniazid

Question 6

Rifampin- MOA

Answer 6

Inhibits bacterial mRNA synthesis, blocks DNA transcription

Question 7

Rifampin- AE

Answer 7

N/V rash, hepatitis, renal failure

Question 8

Rifampin- Monitoring

Answer 8

Cr, CBC, Plt, LFTs Q2-4 weeks

Question 9

Pyrazinamide- Indications

Answer 9

First line tx in combination with isoniazid & rifampin

Question 10

Pyrazinamide- MOA

Answer 10

Unknown- bactericidal for actually dividing organsims

Question 11

Pyrazinamide- AE

Answer 11

anorexia, rash, hepatotoxicity, N/V, urticaria

Question 12

Pyrazinamide- Monitoring

Answer 12

Cr, LFTs, uric acid

Question 13

Ethambutol- Indications

Answer 13

Supplemental Tb tx

Question 14

Ethambutol- MOA

Answer 14

Inhibits synthesis of cell wall

Question 15

Ethambutol- AE

Answer 15

Optic neuritis- diminished visual acuity, loss of red/ green discrimination
- Gout exacerbation

Question 16

Ethambutol- Monitoring

Answer 16

Vision & uric acid

Question 17

Active Tb therapy

Answer 17

6 months DOT total

• 2 months rifampin, pyrazinamide, isoniazed, ethnambutol
• 4 months isoniazed, rifampin,

Question 18

Latent Tb

Answer 18

• 9 month isoniazid with supplemental pyroxidine
• 2 months of rifampin & pyrazinamide
• 4 months rifampin

Question 19

Drug resistant Tb

Answer 19

Depends on resistance

- Continue until culture conversion then 2 drug regimen for 12 additional months