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Emma Step 1 > Pharm - Repro (FA, not in sketchy) > Flashcards

Pharm - Repro (FA, not in sketchy) Flashcards

1
Q

goserelin

A

MOA: GnRH analog
- continuous admin = transiently agonists, then antagonists

use: uterine fibroids. endometriosis, precocious puberty, prostate CA, infertility, breast cancer

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2
Q

leuprolide

A

MOA: GnRH analog
- continuous admin = transiently agonists, then antagonists

use: uterine fibroids. endometriosis, precocious puberty, prostate CA, infertility, breast cancer

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3
Q

Degarelix

A

MOA: GnRH antagonist, no start-up flare

use: prostate cancer

AE: hot flashes, liver toxicity

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4
Q

DES

A

MOA: binds estrogen r

use: hypOgonadism or ovarian failure, menstrual abnormalities (combined OCPs), hormone replacement therapy

AE: inc risk endometrial cancer if given w/o progesterone, bleeding, clear cell adenoCA of vagina in females exposed to DES in utero, inc risk thrombi

contraindications: ER + breast cancer, DVT hx, tobacco use >35 y/o

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5
Q

mestranol

A

MOA: binds estrogen r

use: hypOgonadism or ovarian failure, menstrual abnormalities (combined OCPs), hormone replacement therapy

AE: inc risk endometrial cancer if given w/o progesterone, bleeding, clear cell adenoCA of vagina in females exposed to DES in utero, inc risk thrombi

contraindications: ER + breast cancer, DVT hx, tobacco use >35 y/o

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6
Q

clomiphene

A

MOA: SERM, antagonist of estrogen r in hypothalamus; prevents normal fb inhibition and inc release of LH and inc FSH from pituitary to stimulate ovulation

use: infertility due to anovulation

AE: hot flashes, must simultaneous preg, ovarian enlargement, visual disturbances

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7
Q

tamoxifen

A

MOA: SERM, antagonist at breast, agonist at bone/uterus

use: tx/prevent recurrence of ER/PR + breast cancer

AE: inc risk of thromboembolic events (espec w/ smoking) and endometrial cancer

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8
Q

anastrozole

A

MOA: aromatase inhibitor, inhibits peripheral conversion of androgens to estrogen

use: ER + breast cancer in post-menopausal women

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9
Q

levonorgestrel

A

MOA: progestin, binds progesterone r, dec growth and inc vasculariz of endometrium, thickens cervical mucus

use: contraception, endometrial cancer, abnormal uterine bleeding

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10
Q

medroxyprogesterone

A

MOA: progestin, binds progesterone r, dec growth and inc vasculariz of endometrium, thickens cervical mucus

use: contraception, endometrial cancer, abnormal uterine bleeding

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11
Q

etonogestrel

A

MOA: progestin, binds progesterone r, dec growth and inc vasculariz of endometrium, thickens cervical mucus

use: contraception, endometrial cancer, abnormal uterine bleeding

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12
Q

norethindrone

A

MOA: progestin, binds progesterone r, dec growth and inc vasculariz of endometrium, thickens cervical mucus

use: contraception, endometrial cancer, abnormal uterine bleeding

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13
Q

megestrol

A

MOA: progestin, binds progesterone r, dec growth and inc vasculariz of endometrium, thickens cervical mucus

use: contraception, endometrial cancer, abnormal uterine bleeding

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14
Q

mifepriston

A

MOA: antiprogestin, competitive inhibitor at progesterone r

use: termination of pregnancy (with misoprostol)

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15
Q

ulipristal

A

MOA: antiprogestin, competitive inhibitor at progesterone r

use: termination of pregnancy (with misoprostol)

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16
Q

combined contraception

A

progestins and ethinyl estradiol

MOA: inhib LH/FSH –> no estrogen surge –> no LH surge –> no ovulation

progestins also thicken cervical mucus and inhibit endometrial proliferation (less suitable envio for implantation)

AE: breakthrough menstrual bleeding, breast tenderness, VTE, hepatic adenomas

contraindications: smokers > 35 y/o, pt w/ inc risk CVD, migrane (esp w/ aura), breast cancer, liver disease

17
Q

tocolytics

A

terbutaline
nifedipine
indomethacin

18
Q

danazol

A

MOA: synthetic androgen, acts as partial agonist at androgen r

use: endometriosis, hereditary angioedema

AE: weight gain, edema, acne, hirsutism, masculinization, dec HDL levels, hepatotoxicity, idiopathic intracranial HTN

19
Q

testosterone/methytestosterone AE

A

dec intratesticular testosterone in male by inhibiting release of LH (via neg fb), premature closure of epiphyseal plates, inc LDL, dec HDL

20
Q

finasteride

A

MOA: 5a-reductase inhibitor (dec conversion of testosterone to DHT)

use: BPH, male-pattern baldness

AE: gynecomastia and sexual dysfunction

21
Q

flutamide

A

MOA: nonsteroidal competitive inhibitor at androgen r

use: prostate CA

22
Q

bicalutamide

A

MOA: nonsteroidal competitive inhibitor at androgen r

use: prostate CA

23
Q

apalutamide

A

MOA: nonsteroidal competitive inhibitor at androgen r

use: prostate CA

24
Q

enzalutamide

A

MOA: nonsteroidal competitive inhibitor at androgen r

use: prostate CA

25
Q

minoxidil

A

MOA: direct arteriolar vasodilator

use: androgenetic alopecia (pattern baldness), severe refractory HTN

Emma Step 1 (17 decks)

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