Pharm - Immuno (FA, not in sketchy) Flashcards
cyclosporine
MOA: binds cyclophilin, inhib calcineurin –> inhib NFAT –> blocks T-cell activ by preventing IL-2 transc
^sim MOA as tarcolismus
use: prevent transplant rejection, psoriasis, RA
AE: highly NEPHROTOX. admin w/ diltiazem to offset, hypERuricemia and gout, neurotoxicity (tremor), hypERglycemia, gingival hypERplasia, hirsutism
basiliximab
MOA: monoclonal Ab, blocks IL-2R
use: kidney transplant rejection prophylaxis
AE: edema, hypERtension, tremor
adalimumab
MOA: soluble TNF-a Ab
use: IBD, RA, AK, psoriasis
AE: TB reactiv, drug-induced lupus
infliximab
MOA: soluble TNF-a Ab
use: IBD, RA, AK, psoriasis
AE: TB reactiv, drug-induced lupus
certolizumab
MOA: soluble TNF-a Ab
use: IBD, RA, AK, psoriasis
AE: TB reactiv, drug-induced lupus
golimumab
MOA: soluble TNF-a Ab
use: IBD, RA, AK, psoriasis
AE: TB reactiv, drug-induced lupus
Etanercept
MOA: fusion protein (decoy receptor for TNF-a + IgG1 Fc), produced by recombinant DNA
Eculizumab
MOA: anti-complement protein C5
use: paroxysmal nocturnal hemoglobinuria
Ixekizumab
MOA: anti-IL-17A
use: psoriasis, psoriatic arthritis
Secukinumab
MOA: anti-IL17A
use: psoriasis, psoriatic arthritis
Natalizumab
MOA: anti-alpha4-integrin (WBC adhesion)
use: MS, Crohn
AE: risk of PML in pt with JC virus
Ustekinumab
MOA: IL-12/IL-23
use: psoriasis, psoriatic arthritis
filgrastim
MOA: colony stimulating factor (G-CSF)
use: leukopenia, recovery of granulocyte and monocyte counts
sagramostim
MOA: colony stimulating factor (GM-CSF)
use: leukopenia, recovery of granulocyte and monocyte counts
romiplostim
MOA: TPO analog, platelet stimulator
use: AI thrombocytopenia
