Neoplasia (FA) Flashcards by Alegra Mendez

ALK

oncogene

receptor tyrosine kinase

lung adenoCA

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BRAF

oncogene

serine/threonine kinase

melanoma
NHL
papillary thyroid CA
hairy cell leukemia

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c-KIT

oncogene

cytokine receptor

GI stromal tumor

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MYCL1

oncogene

tfac

lung tumor

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N-myc

oncogene

tfac

Neuroblastoma

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APC

tumor suppressor

neg regulator of B-catenin/WNT path

colorectal cancer

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CDK2A

tumor suppressor

p16, blocks G1—>S

melanoma, panc cancer

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DCC

tumor suppressor

(Deleted) in Colon Cancer

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SMAD4 (DPC4)

tumor suppressor

(Deleted) in Pancreatic Cancer

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MEN1

tumor suppressor

Multiple Endocrine Neoplasia type I

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NF1

tumor suppressor

neurofibromin (Ras GTPase activating protein)

Neurofibromatosis 1

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NF2

tumor suppressor

Merlin (Schwannomin) protein

Neurofibromatosis 2

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PTEN

tumor suppressor

Neg regulator of PI3k/AKT pathway

Prostate
breasT
Endometrial

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TP53

tumor suppressor

most human cancers
Li-Fraumeni syndrome
SBLA cancer syndrome (Sarcoma, Breast, Leukemia, Adrenal gland)

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TSC1

tumor suppressor

hamartin

tuberous sclerosis

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TSC2

tumor suppressor

tuberin

tuberous sclerosis

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VHL

tumor suppressor

inhibits hypoxia-inducible factor Ia

VHL disease

WT1

tumor suppressor

urogenital development transcription factor

Wilms tumor (nephroblastoma)

aromatic amines

benzidine, 2-naphthylamine

transitional cell CA

nitrosamines

(smoked foods)

gastric cancer

vinyl chloride

liver, angiosarcoma

CA 19-9

pancreatic adenoCA

CA 15-3/CA 27-29

breast cancer

desMin

Muscle tumor marker

GFAP

neuroGlia (astocytoma, Glioblastoma)

S-100

neural crest cells | melanoma, schwannoma, Langerhans cell histiocytosis

TRAP

tartate-resistabt acid phosphatase | Hairy cell leukemia

viMENtin

mesenchymal tissue tumors + endometrial, renal cell, meningioma

P-glycoprotein

aka MDR1 adrenocortical CA

PSaMMOMa bodies

``` Papillary carcinoma of thyroid Somatostatinoma Meningioma Malignant Mesothelioma Ovarian serous papillary cystadenocarcinoma Prolactinoma (Milk) ```

acanthosis nigricans

gastric adenoCA and other visceral malignancies

hypertrophic osteoarthropathy

adenoCA of the lung

pure red cell aplasia

anemia w/ low reticulocytes assoc w/ thymoma

Good syndrome

hypOgammaglobulinemia assoc w/ thymoma

trousseau syndrome

migratory superficial phlebitis assoc w/ adenoCA *PANCREATIC

nonbacterial thrombotic (marantic) endocarditis

assoc w/ adenoCA *PANCREATIC

anti-NMDA receptor encephalitis

ovarian teratoma

"dancing eyes, dancing feet"

opsoclonus, myoclonus ataxia syndrome neuroblastoma small cell lung cancer

paraneoplastic cerebellar degeneration

Abs against antigens in purkinje cells small cell lung cancer gynecologic and breast cancers hodgkin lymphoma

paraneoplastic encephalomyelitis

Abs against Hu antigens in neurons small cell lung cancer

Lambert-eaton

small cell lung cancer

myasthenia gravis

thymoma