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Emma Step 1 > Neoplasia (FA) > Flashcards

Neoplasia (FA) Flashcards

1
Q

ALK

A

oncogene

receptor tyrosine kinase

lung adenoCA

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2
Q

BRAF

A

oncogene

serine/threonine kinase

melanoma
NHL
papillary thyroid CA
hairy cell leukemia

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3
Q

c-KIT

A

oncogene

cytokine receptor

GI stromal tumor

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4
Q

MYCL1

A

oncogene

tfac

lung tumor

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5
Q

N-myc

A

oncogene

tfac

Neuroblastoma

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6
Q

APC

A

tumor suppressor

neg regulator of B-catenin/WNT path

colorectal cancer

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7
Q

CDK2A

A

tumor suppressor

p16, blocks G1—>S

melanoma, panc cancer

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8
Q

DCC

A

tumor suppressor

(Deleted) in Colon Cancer

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9
Q

SMAD4 (DPC4)

A

tumor suppressor

(Deleted) in Pancreatic Cancer

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10
Q

MEN1

A

tumor suppressor

Multiple Endocrine Neoplasia type I

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11
Q

NF1

A

tumor suppressor

neurofibromin (Ras GTPase activating protein)

Neurofibromatosis 1

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12
Q

NF2

A

tumor suppressor

Merlin (Schwannomin) protein

Neurofibromatosis 2

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13
Q

PTEN

A

tumor suppressor

Neg regulator of PI3k/AKT pathway

Prostate
breasT
Endometrial

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14
Q

TP53

A

tumor suppressor

most human cancers
Li-Fraumeni syndrome
SBLA cancer syndrome (Sarcoma, Breast, Leukemia, Adrenal gland)

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15
Q

TSC1

A

tumor suppressor

hamartin

tuberous sclerosis

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16
Q

TSC2

A

tumor suppressor

tuberin

tuberous sclerosis

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17
Q

VHL

A

tumor suppressor

inhibits hypoxia-inducible factor Ia

VHL disease

18
Q

WT1

A

tumor suppressor

urogenital development transcription factor

Wilms tumor (nephroblastoma)

19
Q

aromatic amines

benzidine, 2-naphthylamine

A

transitional cell CA

20
Q

nitrosamines

A

(smoked foods)

gastric cancer

21
Q

vinyl chloride

A

liver, angiosarcoma

22
Q

CA 19-9

A

pancreatic adenoCA

23
Q

CA 15-3/CA 27-29

A

breast cancer

24
Q

desMin

A

Muscle tumor marker

25
Q

GFAP

A

neuroGlia (astocytoma, Glioblastoma)

26
Q

S-100

A

neural crest cells

melanoma, schwannoma, Langerhans cell histiocytosis

27
Q

TRAP

A

tartate-resistabt acid phosphatase

Hairy cell leukemia

28
Q

viMENtin

A

mesenchymal tissue tumors + endometrial, renal cell, meningioma

29
Q

P-glycoprotein

A

aka MDR1

adrenocortical CA

30
Q

PSaMMOMa bodies

A 
Papillary carcinoma of thyroid
Somatostatinoma
Meningioma
Malignant Mesothelioma
Ovarian serous papillary cystadenocarcinoma
Prolactinoma (Milk)
31
Q

acanthosis nigricans

A

gastric adenoCA and other visceral malignancies

32
Q

hypertrophic osteoarthropathy

A

adenoCA of the lung

33
Q

pure red cell aplasia

A

anemia w/ low reticulocytes

assoc w/ thymoma

34
Q

Good syndrome

A

hypOgammaglobulinemia

assoc w/ thymoma

35
Q

trousseau syndrome

A

migratory superficial phlebitis

assoc w/ adenoCA *PANCREATIC

36
Q

nonbacterial thrombotic (marantic) endocarditis

A

assoc w/ adenoCA *PANCREATIC

37
Q

anti-NMDA receptor encephalitis

A

ovarian teratoma

38
Q

“dancing eyes, dancing feet”

A

opsoclonus, myoclonus ataxia syndrome

neuroblastoma
small cell lung cancer

39
Q

paraneoplastic cerebellar degeneration

A

Abs against antigens in purkinje cells

small cell lung cancer
gynecologic and breast cancers
hodgkin lymphoma

40
Q

paraneoplastic encephalomyelitis

A

Abs against Hu antigens in neurons

small cell lung cancer

41
Q

Lambert-eaton

A

small cell lung cancer

42
Q

myasthenia gravis

A

thymoma

Emma Step 1 (17 decks)

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