Pharm - ID (FA, not in sketchy)

Question 1

fidaxomicin

Answer 1

MOA: macrocyclic antibiotic, inhibits sigma subunit of RNAP

USE: C difficile

• oral admin with minimal systemic absorption, resulting in high fecal []
• less effect on normal colonic flora than vancomycin

Question 2

pyrimethamine

Answer 2

MOA: inhib parasitic dihydrofolate reductase

USE: malaria and toxoplasmosis