Pharm - Neuro (FA, not in sketchy)

Question 1

Memantine

Answer 1

MOA: NDMA receptor antagonist; helps prevent excitotoxicity (mediated by Ca)

use: moderate to advanced dementia

AE: dizziness, confusion, hallucinations

Question 2

Riluzole

Answer 2

MOA: dec neuron glutamate excitotoxicity

use: ALS (inc survival)