Pharm - Heme-Onc (FA, not in sketchy)

Question 1

procarbazine

Answer 1

MOA: unknown, cell cycle phase NON-specific alkylator

USE: Hodgkin lymphoma, brain tumors

AE: brain marrow suppression, pulm tox, leukemia, disulfiram-like rxn, tyramine-induced hypertensive crisis (cheese, wine, fava)

Question 2

panitumumab

Answer 2

MOA: mAb against EGFR

USE: stage IV colorectal cancer (KRAS), head and neck cancer

AE: rash, inc LFTs, diarrhea

Question 3

dasatinib

Answer 3

MOA: TK inhibitor of bcr-abl (encoded by PHL fusion in CML) and c-kit (common in GI stromal tumors)

USE: CML, GI stromal tumors

AE: fluid retention

Question 4

nilotinib

Answer 4

MOA: TK inhibitor of bcr-abl (encoded by PHL fusion in CML) and c-kit (common in GI stromal tumors)

USE: CML, GI stromal tumors

AE: fluid retention

Question 5

dabrafenib

Answer 5

MOA: small molec inhibitor of V600E BRAF positive malignant melanoma

*often coadmin w/ MEK inhib (trametinib)

USE: metastatic melanoma