Pharm Rapid Fire Associations Flashcards by Erin Kretovics

Q

hand foot syndrome

A

capcitabine

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Q

DPD allelic variation

A

5FU toxicity

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Q

CDA resistance

A

ara-C

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Q

areas of lots of CDA

A

liver and spleen

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Q

DHFR inhibitor

A

MTX

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Q

leukovorin rescue

A

HDMTX

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Q

HPRT activation

A

6-MP, 6-TG

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Q

dose adustment of pt on allopurinol

A

6-MP , decrease dose

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Q

hairy cell leukemia

A

cladribine

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Q

pancreatic cancer

A

gemcitibine

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Q

neurotoxicity

A

vinchristine

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Q

build up of microtubules in dividing cell

A

taxanes

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Q

cardiotoxicity

A

anthracyclines - sp doxorubicin

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Q

topoisomerase II inhibition

A

epipodophyllotoxins - etoposide, teniposide

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Q

topoisomerase I inhibition

A

camtothicins - irinotecan, topotecan

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Q

pulmonary fibrosis

A

bleomycin

Q

acrolien nephrotoxicity

A

N-mustards - cyclophospamide

Q

chloracetaldehyde neurotoxicity

A

isofosfamide

Q

CML

A

busulfan

Q

penetrates CNS - good to use for brain tumors

A

nitrosurias - carmustine, lomustine

Q

H+ activation in the gut to MTIC

A

temzolomide

Q

MGMT silencing

A

triazines - better outcomes

Q

Cu dependent transport

A

cisplatin

Q

hyperphosphatemia
hyperkalemia
hyperuricemia

A

tumor lysis syndrome

severe, possibly life threatening diarrhea

irinotecan

AML

ara-c

monofunctional akylating agents

- nitrosurias | - trazines

bifunstional alkylating agents

- nitrogen mustards - "other" - aziridines

alkylating agents that penetrate the CNS

-carmustine -lomustine -temzolomide -procabazine (all are monofxnl)

cold induced neuropathy

oxoplatin

renal + ototoxicity

cisplatin

tx of VHL + RCC

- sunitimab + sofrafenib to inhibit VEGFR + PDGFR | - bevacisumab to inihibit VEGF ligand

reversible aromatase inhibitor

anastrol

irreversible aromatase inhibitor

exemestane

malignant pleural mesothelioma

pemetrexid

Fe mediated free radical generation

bleomycin