Fitz - DNA alkylating agents

Question 1

triazenes

Answer 1

• decarbazine
• procarbazine
• temozolomide

Question 2

monofunctional agents

Answer 2

triazenes, nitrosurias

Question 3

tx: decarbazine

Answer 3

met melanoma

Question 4

tx: procarbazine

Answer 4

malignant glioma

Question 5

tx: temozolomide

Answer 5

treatment resistant glioma and astrocytoma

Question 6

nitrosurias

Answer 6

• carmustine
• lomustine
• streptozocin

Question 7

tx: carmustine

Answer 7

brain tumors, lymphoma, melanoma

Question 8

tx: lomustine

Answer 8

brain tumors, lymphoma, melanoma

Question 9

tx: streptozocin

Answer 9

insulinomas

Question 10

bifunctional agente

Answer 10

• nitrogen mustards
• melphalan (PO)
• chlorambucil (PO)
• busulfan (PO)
• aziridines

Question 11

nitrogen mustards

Answer 11

• cyclophospamide
• ifosfamide
• mechlorethamine

Question 12

tx: melphalan

Answer 12

multiple myeloma

Question 13

tx: chlorambucil

Answer 13

CLL

Question 14

tx: busulfan

Answer 14

CML

Question 15

aziridines

Answer 15

• thiotepa
• mitomycin C
• altretamine

Question 16

tx: thiotepa

Answer 16

breast, ovarian, bladder ca

Question 17

tx: mitromycin C

Answer 17

breast and GI ca

Question 18

tx: altretamine

Answer 18

recurrent ovarian ca resistant to other alkylating agents

Question 19

repair insensitive bifunctional agent

Answer 19

mitomycin

Question 20

repair sensitive bifunctional agents

Answer 20

• nitrogen mustards
• thiotepa
• busulfan
• chloroethyl-nitrosuria

Question 21

CCNS drugs are dependent on

Answer 21

dose

Question 22

AE of mechlorethamine upon admin

Answer 22

blisters and necrosis if extravasation occurs

Question 23

urotoxic metabolit of cyclophospamide and isofosfamide

Answer 23

acrolein

Question 24

neurotoxic metabolit of ifosfamide

Answer 24

chloracetaldehyde

Question 25

DLT: nitrosurias

Answer 25

myelosuppression

Question 26

ROA: decarbazine

Answer 26

IV

Question 27

ROA: temozolomide

Answer 27

PO

Question 28

triazene with good CNS penetration

Answer 28

Temzolomide ( and procarbazine)

Question 29

better outcomes for temozolomide tx seen in pts with

Answer 29

MGMT silencing

Question 30

organo-platinum drugs

Answer 30

- cisplatin - carboplatin - oxaloplatin

Question 31

organo-platinum that is a more stable analog of cisplatin

Answer 31

carboplatin

Question 32

tx: cisplatin

Answer 32

testicular ca, ovarian ca, NSCL

Question 33

DLT: cisplatin

Answer 33

renal, severe nausea/vomiting , ototoxicity

Question 34

tx: carboplatin

Answer 34

ovarian ca

Question 35

DLT: carboplatin

Answer 35

neutropenai

Question 36

tx: oxaloplatin

Answer 36

colorectal cancer

Question 37

DLT: oxaloplatin

Answer 37

neutropenia, neuropathy (cold induced)

Question 38

nephrotoxicity from cisplatin manifests as

Answer 38

low GFR, high serum Cr, reduced serum Mg and K 10 d post tx

Question 39

distinguishing factor btwn cisplatin renal tox and tumor lysis syndrome

Answer 39

K low with cisplatin, K high with tumor lysis