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Heme & Lymph > Fitz - DNA alkylating agents > Flashcards

Fitz - DNA alkylating agents Flashcards

1
Q

triazenes

A
  • decarbazine
  • procarbazine
  • temozolomide
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2
Q

monofunctional agents

A

triazenes, nitrosurias

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3
Q

tx: decarbazine

A

met melanoma

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4
Q

tx: procarbazine

A

malignant glioma

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5
Q

tx: temozolomide

A

treatment resistant glioma and astrocytoma

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6
Q

nitrosurias

A
  • carmustine
  • lomustine
  • streptozocin
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7
Q

tx: carmustine

A

brain tumors, lymphoma, melanoma

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8
Q

tx: lomustine

A

brain tumors, lymphoma, melanoma

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9
Q

tx: streptozocin

A

insulinomas

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10
Q

bifunctional agente

A
  • nitrogen mustards
  • melphalan (PO)
  • chlorambucil (PO)
  • busulfan (PO)
  • aziridines
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11
Q

nitrogen mustards

A
  • cyclophospamide
  • ifosfamide
  • mechlorethamine
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12
Q

tx: melphalan

A

multiple myeloma

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13
Q

tx: chlorambucil

A

CLL

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14
Q

tx: busulfan

A

CML

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15
Q

aziridines

A
  • thiotepa
  • mitomycin C
  • altretamine
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16
Q

tx: thiotepa

A

breast, ovarian, bladder ca

17
Q

tx: mitromycin C

A

breast and GI ca

18
Q

tx: altretamine

A

recurrent ovarian ca resistant to other alkylating agents

19
Q

repair insensitive bifunctional agent

A

mitomycin

20
Q

repair sensitive bifunctional agents

A
  • nitrogen mustards
  • thiotepa
  • busulfan
  • chloroethyl-nitrosuria
21
Q

CCNS drugs are dependent on

A

dose

22
Q

AE of mechlorethamine upon admin

A

blisters and necrosis if extravasation occurs

23
Q

urotoxic metabolit of cyclophospamide and isofosfamide

A

acrolein

24
Q

neurotoxic metabolit of ifosfamide

A

chloracetaldehyde

25
Q

DLT: nitrosurias

A

myelosuppression

26
Q

ROA: decarbazine

A

IV

27
Q

ROA: temozolomide

A

PO

28
Q

triazene with good CNS penetration

A

Temzolomide ( and procarbazine)

29
Q

better outcomes for temozolomide tx seen in pts with

A

MGMT silencing

30
Q

organo-platinum drugs

A
  • cisplatin
  • carboplatin
  • oxaloplatin
31
Q

organo-platinum that is a more stable analog of cisplatin

A

carboplatin

32
Q

tx: cisplatin

A

testicular ca, ovarian ca, NSCL

33
Q

DLT: cisplatin

A

renal, severe nausea/vomiting , ototoxicity

34
Q

tx: carboplatin

A

ovarian ca

35
Q

DLT: carboplatin

A

neutropenai

36
Q

tx: oxaloplatin

A

colorectal cancer

37
Q

DLT: oxaloplatin

A

neutropenia, neuropathy (cold induced)

38
Q

nephrotoxicity from cisplatin manifests as

A

low GFR, high serum Cr, reduced serum Mg and K 10 d post tx

39
Q

distinguishing factor btwn cisplatin renal tox and tumor lysis syndrome

A

K low with cisplatin, K high with tumor lysis

Heme & Lymph (11 decks)

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