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Heme & Lymph > Fitz - Antimitotic/microtubule drugs & Drugs that break DNA strands > Flashcards

Fitz - Antimitotic/microtubule drugs & Drugs that break DNA strands Flashcards

1
Q

inhibit tubulin polymerization > block assembly of microtubules

A

Vinca alkaloids - start with “vin”

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2
Q

enhance tubulin polymerzation > stabilize microtubules

A

taxanes - “tax” in middle

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3
Q

tx: vinblastine

A

testicular cancer, lymphomas, neuroblastoma

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4
Q

tx: vincristine

A

ALL (peds), lymphoma, neuroblastoma, Wilm’s, Ewings sarcoma

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5
Q

tx: vinorelbine

A

advances NSCL cancer

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6
Q

tx: paclitaxel

A

advanced breast and ovarian ca (w/ cisplatin)

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7
Q

tx: docetaxel

A

advanced breast, ovarian recurrence

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8
Q

DLT: vinblastine

A

BM suppression, vesicant - blisters

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9
Q

DLT: vincristine

A

neurotox, peripheral neuropathy, paralytic ileus, vesicant - blisters

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10
Q

DLT: vinorelbine

A

BM suppression, vesicant - blisters

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11
Q

DLT: paclitaxel

A

neutripenua, thormbocytopenia, peripheral neuopathy, severe HSN during infusion

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12
Q

DLT: docetaxel

A

neutropenia, peripheral neuropathy

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13
Q

phase of the cell cycle that vinca alkaloids and taxanes act at

A

M phase

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14
Q

sub for vincristine when neuropathy is severe

A

vinbastine

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15
Q

mode of MDR to vinca alkaloids and taxanes

A

increased expression of P-glycoprotein > increased extrusion of drug from cells

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16
Q

vinca alkaloids and taxanes administration and metabolism

A

IV, hepatic

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17
Q

topoisomerase II inhibition > double strand DNA breaks

A

epipophyllotoxins (etoposide, teniposide)

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18
Q

topoisomerase I inhibition > single strand DNA breaks

A

camptothecins (irinotecan, topotecan)

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19
Q

tx: etoposide

A

oat cell carcinoma of the lung, testicular cancer

20
Q

tx: teniposide

A

glioma and neuroblastoma

21
Q

tx: irinotecan

A

met colorectal cancer

22
Q

tx: topotecan

A

2nd line after irinotecan

23
Q

DLT: etoposide

A

leukopenia, 2ndary cancer

24
Q

DLT: teniposide

A

leukopenia

25
Q

DLT: irinotecan

A

severe diarrhea (life threatning), myelosuppressio

26
Q

DLT: topotecan

A

neutropenia, mucositis

27
Q

phase of the cell cycle that camptothecins (irinotecan, topotecan) work in

A

S phase

28
Q

phase of the cell cycle that epipophyllotoxins (etoposide, teniposide) work in

A

CCNS

29
Q

Fe2+/3+ mediated free radical generation > DNA strand breaks

A

bleomycin

30
Q

DNA intercalating agents

A
  • antibiotics

- anthracyclins

31
Q
  • inhibition of topoisomerase I
  • DNA intercalating agents
  • free radical generation > DNA strand breaks
A
  • doxorubicin
  • danunorubicin
  • epirubicin
  • idrarubicin
32
Q

mitoxantrone

A

inhibits topo II

33
Q

anthracyclines

A
  • doxorubicin
  • danunorubicin
  • epirubicin
  • mitoxantrone
34
Q

tx: bleomycin

A

testicular cancer

35
Q

tx: doxorubicin and epirubicin

A

widespread breast, ovaria, lung, thyroid, lympoma, sarcoma

36
Q

tx: danunorubicin

A

AML, ALL

37
Q

tx: idrarubicin

A

AML, ALL, CML in blast crisis

38
Q

tx: mitoxantrone

A

breast, prostate, NHL

39
Q

DLT: bleomycin

A

dyspnea, rales, dry cough > pulmonary fibrosis

40
Q

DNL: “-rubicin” drugs

A

cardiotox, dilated cardiomyopathy, CHF occurs over time; myelosupprssion, mucositis

41
Q

DLT: mitoxantrone

A

similar to -rubicins

42
Q

cotreatment with these drugs increases risk of cardiotoxicity

A
  • paclitaxel

- trastuzumab

43
Q

missing enzyme in skin and lung that metabolize bleomycin

A

hydrolase

44
Q

stage of the cell cycle that belomycin works at

A

G2 phase

45
Q

stage of the cell cycle that anthracyclines work at

A

S and G2 phases

Heme & Lymph (11 decks)

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