Fitz - Antimitotic/microtubule drugs & Drugs that break DNA strands

Question 1

inhibit tubulin polymerization > block assembly of microtubules

Answer 1

Vinca alkaloids - start with “vin”

Question 2

enhance tubulin polymerzation > stabilize microtubules

Answer 2

taxanes - “tax” in middle

Question 3

tx: vinblastine

Answer 3

testicular cancer, lymphomas, neuroblastoma

Question 4

tx: vincristine

Answer 4

ALL (peds), lymphoma, neuroblastoma, Wilm’s, Ewings sarcoma

Question 5

tx: vinorelbine

Answer 5

advances NSCL cancer

Question 6

tx: paclitaxel

Answer 6

advanced breast and ovarian ca (w/ cisplatin)

Question 7

tx: docetaxel

Answer 7

advanced breast, ovarian recurrence

Question 8

DLT: vinblastine

Answer 8

BM suppression, vesicant - blisters

Question 9

DLT: vincristine

Answer 9

neurotox, peripheral neuropathy, paralytic ileus, vesicant - blisters

Question 10

DLT: vinorelbine

Answer 10

BM suppression, vesicant - blisters

Question 11

DLT: paclitaxel

Answer 11

neutripenua, thormbocytopenia, peripheral neuopathy, severe HSN during infusion

Question 12

DLT: docetaxel

Answer 12

neutropenia, peripheral neuropathy

Question 13

phase of the cell cycle that vinca alkaloids and taxanes act at

Answer 13

M phase

Question 14

sub for vincristine when neuropathy is severe

Answer 14

vinbastine

Question 15

mode of MDR to vinca alkaloids and taxanes

Answer 15

increased expression of P-glycoprotein > increased extrusion of drug from cells

Question 16

vinca alkaloids and taxanes administration and metabolism

Answer 16

IV, hepatic

Question 17

topoisomerase II inhibition > double strand DNA breaks

Answer 17

epipophyllotoxins (etoposide, teniposide)

Question 18

topoisomerase I inhibition > single strand DNA breaks

Answer 18

camptothecins (irinotecan, topotecan)

Question 19

tx: etoposide

Answer 19

oat cell carcinoma of the lung, testicular cancer

Question 20

tx: teniposide

Answer 20

glioma and neuroblastoma

Question 21

tx: irinotecan

Answer 21

met colorectal cancer

Question 22

tx: topotecan

Answer 22

2nd line after irinotecan

Question 23

DLT: etoposide

Answer 23

leukopenia, 2ndary cancer

Question 24

DLT: teniposide

Answer 24

leukopenia

Question 25

DLT: irinotecan

Answer 25

severe diarrhea (life threatning), myelosuppressio

Question 26

DLT: topotecan

Answer 26

neutropenia, mucositis

Question 27

phase of the cell cycle that camptothecins (irinotecan, topotecan) work in

Answer 27

S phase

Question 28

phase of the cell cycle that epipophyllotoxins (etoposide, teniposide) work in

Answer 28

CCNS

Question 29

Fe2+/3+ mediated free radical generation > DNA strand breaks

Answer 29

bleomycin

Question 30

DNA intercalating agents

Answer 30

- antibiotics | - anthracyclins

Question 31

- inhibition of topoisomerase I - DNA intercalating agents - free radical generation > DNA strand breaks

Answer 31

- doxorubicin - danunorubicin - epirubicin - idrarubicin

Question 32

mitoxantrone

Answer 32

inhibits topo II

Question 33

anthracyclines

Answer 33

- doxorubicin - danunorubicin - epirubicin - mitoxantrone

Question 34

tx: bleomycin

Answer 34

testicular cancer

Question 35

tx: doxorubicin and epirubicin

Answer 35

widespread breast, ovaria, lung, thyroid, lympoma, sarcoma

Question 36

tx: danunorubicin

Answer 36

AML, ALL

Question 37

tx: idrarubicin

Answer 37

AML, ALL, CML in blast crisis

Question 38

tx: mitoxantrone

Answer 38

breast, prostate, NHL

Question 39

DLT: bleomycin

Answer 39

dyspnea, rales, dry cough > pulmonary fibrosis

Question 40

DNL: "-rubicin" drugs

Answer 40

cardiotox, dilated cardiomyopathy, CHF occurs over time; myelosupprssion, mucositis

Question 41

DLT: mitoxantrone

Answer 41

similar to -rubicins

Question 42

cotreatment with these drugs increases risk of cardiotoxicity

Answer 42

- paclitaxel | - trastuzumab

Question 43

missing enzyme in skin and lung that metabolize bleomycin

Answer 43

hydrolase

Question 44

stage of the cell cycle that belomycin works at

Answer 44

G2 phase

Question 45

stage of the cell cycle that anthracyclines work at

Answer 45

S and G2 phases