Fitz - Anti-folate anti-metabolites Flashcards
1
Q
MOA: MTX
A
competitive inhibition of DHF reductase»blocks synthesis of purines
2
Q
can circumvent MTX resistance d/t broader spectrum of activity
A
pemetrexed
3
Q
tx: MTX
A
- ped leukemias
- primary CNS lymphomas
- NHL
- GI, colon, breast, and H/N carcinomas
4
Q
tx: pemetrexed
A
malignant pleural mesothelioma
5
Q
rescue for high dose MTX
A
leucovorin
6
Q
excretion of intermediate/low dose MTX
A
renal
7
Q
DLT: MTX
A
- GI toxicity
- BM suppression - thrombocytopenia and leukopenia
- renal toxicity w/ HDMTX
8
Q
MOA: pemetrexed
A
competitive inhibition of TS and GAR»_space; inhibition of dTMP and purine nucleotide synthesis
9
Q
tx regimen increases survival in malignant pleural mesothelioma
A
pemetrexed + cisplatin
