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Heme & Lymph > Kruse - Pharm of Anemia > Flashcards

Kruse - Pharm of Anemia Flashcards

1
Q

Tx: acute Fe toxicity

A
  • whole bowel irrigaiton

- parenteral deferoxamine

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2
Q

oral Fe chelator that reduces liver Fe concentrations

A

deferasirox

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3
Q

megaloblastic macrocytic anemia

A

B12 def

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4
Q

folic acid is absorbed in the

A

jejunum

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5
Q

drugs that cause folic acid def

A
  • methotrexate
  • trimethoprim
  • pyrimethamine
  • LT phenytoin
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6
Q

dosing of rHuEPO

A

once weekly

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7
Q

t1/2: rHuEPO

A

4-8 h

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8
Q

increased glycosylated form of EPO

A

darbepoetin alpha

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9
Q

t1/2:darbepoetin alpha

A

24-26 h

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10
Q

increased retiulocytes d/t EPO seen in

A

10d

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11
Q

rise in Hb & Hct d/t EPO seen in

A

2-6w

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12
Q

filgrastim

A

recomb human G-CSF

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13
Q

t1/2: filgrastim

A

2-3.5h

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14
Q

pegfilgrastim

A

filgrastim + polyethylene glycol

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15
Q

t1/2: pegfilgrastim

A

15-80h

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16
Q

sergramostim

A

GM-CSF

17
Q

t1/2: sergramostim

A
  • IV = 1h

- subQ = 3h

18
Q

MOA: plerixafor

A

reversibly inhbits binding of stromal cell-derived factor-1-alpha

19
Q

myeloid growth factors stimulate

A

JAK/STAT signal transduction pathway

20
Q

AE: filgrastim & pegfilgrastim

A

bone pain

21
Q

peripheral edema and pleural or pericardial effusions can be indicative of what?

A

capillary leak syndrome cause by GM-CSF

22
Q

recombinant megakaryocyte growth factor approved for clinical use

A

oprelvekin

23
Q

romiplostim

A

recomb thrombopoirtin

24
Q

results of romiplostim seen in

A

5 days (post subQ) and peak at 12-15d

25
Q

t1/2: oprelvekin

A

7-8h

26
Q

tx of ppl with ITP

A

romiplostim

27
Q

AE: ferrous sulfate (Oral Fe therapy)

A
  • nausea
  • epigastric pain
  • abd cramps
  • const
  • black stools
  • diarrhea
28
Q

AE: Fe dextran

A
  • HA
  • lightheaded
  • fever
  • arthroalgias
  • N/V
  • back pain
  • flushing
  • urticaria
  • bronchospasm
  • anaphylaxis
29
Q

AE: recombinat human EPO

A
  • HTN
  • thrombotic complications
  • allergic reaction
30
Q

AE: filgrastim and pegfilgrastim

A

Bone pain

31
Q

AE: GM-CSF

A
  • fever
  • malaise
  • arthroalgias
  • myalgias
  • capillary leak syndrome
32
Q

AE: IL-11

A
  • fatigues
  • HA
  • dizziness
  • CV effects
  • hypokalemia
33
Q

AE: romiplostim

A

Mild HA

34
Q

Use in combination with filgrastim results in synergistic increase in CD34+ cell

A

Pelrixafor

Heme & Lymph (11 decks)

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