Kruse - Pharm of Anemia Flashcards
Tx: acute Fe toxicity
- whole bowel irrigaiton
- parenteral deferoxamine
oral Fe chelator that reduces liver Fe concentrations
deferasirox
megaloblastic macrocytic anemia
B12 def
folic acid is absorbed in the
jejunum
drugs that cause folic acid def
- methotrexate
- trimethoprim
- pyrimethamine
- LT phenytoin
dosing of rHuEPO
once weekly
t1/2: rHuEPO
4-8 h
increased glycosylated form of EPO
darbepoetin alpha
t1/2:darbepoetin alpha
24-26 h
increased retiulocytes d/t EPO seen in
10d
rise in Hb & Hct d/t EPO seen in
2-6w
filgrastim
recomb human G-CSF
t1/2: filgrastim
2-3.5h
pegfilgrastim
filgrastim + polyethylene glycol
t1/2: pegfilgrastim
15-80h
sergramostim
GM-CSF
t1/2: sergramostim
- IV = 1h
- subQ = 3h
MOA: plerixafor
reversibly inhbits binding of stromal cell-derived factor-1-alpha
myeloid growth factors stimulate
JAK/STAT signal transduction pathway
AE: filgrastim & pegfilgrastim
bone pain
peripheral edema and pleural or pericardial effusions can be indicative of what?
capillary leak syndrome cause by GM-CSF
recombinant megakaryocyte growth factor approved for clinical use
oprelvekin
romiplostim
recomb thrombopoirtin
results of romiplostim seen in
5 days (post subQ) and peak at 12-15d
t1/2: oprelvekin
7-8h
tx of ppl with ITP
romiplostim
AE: ferrous sulfate (Oral Fe therapy)
- nausea
- epigastric pain
- abd cramps
- const
- black stools
- diarrhea
AE: Fe dextran
- HA
- lightheaded
- fever
- arthroalgias
- N/V
- back pain
- flushing
- urticaria
- bronchospasm
- anaphylaxis
AE: recombinat human EPO
- HTN
- thrombotic complications
- allergic reaction
AE: filgrastim and pegfilgrastim
Bone pain
AE: GM-CSF
- fever
- malaise
- arthroalgias
- myalgias
- capillary leak syndrome
AE: IL-11
- fatigues
- HA
- dizziness
- CV effects
- hypokalemia
AE: romiplostim
Mild HA
Use in combination with filgrastim results in synergistic increase in CD34+ cell
Pelrixafor
