Kruse - Pharm of Anemia

Question 1

Tx: acute Fe toxicity

Answer 1

• whole bowel irrigaiton

- parenteral deferoxamine

Question 2

oral Fe chelator that reduces liver Fe concentrations

Answer 2

deferasirox

Question 3

megaloblastic macrocytic anemia

Answer 3

B12 def

Question 4

folic acid is absorbed in the

Answer 4

jejunum

Question 5

drugs that cause folic acid def

Answer 5

• methotrexate
• trimethoprim
• pyrimethamine
• LT phenytoin

Question 6

dosing of rHuEPO

Answer 6

once weekly

Question 7

t1/2: rHuEPO

Answer 7

4-8 h

Question 8

increased glycosylated form of EPO

Answer 8

darbepoetin alpha

Question 9

t1/2:darbepoetin alpha

Answer 9

24-26 h

Question 10

increased retiulocytes d/t EPO seen in

Answer 10

10d

Question 11

rise in Hb & Hct d/t EPO seen in

Answer 11

2-6w

Question 12

filgrastim

Answer 12

recomb human G-CSF

Question 13

t1/2: filgrastim

Answer 13

2-3.5h

Question 14

pegfilgrastim

Answer 14

filgrastim + polyethylene glycol

Question 15

t1/2: pegfilgrastim

Answer 15

15-80h

Question 16

sergramostim

Answer 16

GM-CSF

Question 17

t1/2: sergramostim

Answer 17

• IV = 1h

- subQ = 3h

Question 18

MOA: plerixafor

Answer 18

reversibly inhbits binding of stromal cell-derived factor-1-alpha

Question 19

myeloid growth factors stimulate

Answer 19

JAK/STAT signal transduction pathway

Question 20

AE: filgrastim & pegfilgrastim

Answer 20

bone pain

Question 21

peripheral edema and pleural or pericardial effusions can be indicative of what?

Answer 21

capillary leak syndrome cause by GM-CSF

Question 22

recombinant megakaryocyte growth factor approved for clinical use

Answer 22

oprelvekin

Question 23

romiplostim

Answer 23

recomb thrombopoirtin

Question 24

results of romiplostim seen in

Answer 24

5 days (post subQ) and peak at 12-15d

Question 25

t1/2: oprelvekin

Answer 25

7-8h

Question 26

tx of ppl with ITP

Answer 26

romiplostim

Question 27

AE: ferrous sulfate (Oral Fe therapy)

Answer 27

- nausea - epigastric pain - abd cramps - const - black stools - diarrhea

Question 28

AE: Fe dextran

Answer 28

- HA - lightheaded - fever - arthroalgias - N/V - back pain - flushing - urticaria - bronchospasm - anaphylaxis

Question 29

AE: recombinat human EPO

Answer 29

- HTN - thrombotic complications - allergic reaction

Question 30

AE: filgrastim and pegfilgrastim

Answer 30

Bone pain

Question 31

AE: GM-CSF

Answer 31

- fever - malaise - arthroalgias - myalgias - capillary leak syndrome

Question 32

AE: IL-11

Answer 32

- fatigues - HA - dizziness - CV effects - hypokalemia

Question 33

AE: romiplostim

Answer 33

Mild HA

Question 34

Use in combination with filgrastim results in synergistic increase in CD34+ cell

Answer 34

Pelrixafor