Fitz - Targeted Therapy & Biologicals Flashcards
1
Q
occupies the ATP cofactor binding site on Bcr-Ab causing inhibition of phosphate transfer to tyrosine kinase
A
imatinib
2
Q
resistance to imatinib
A
mutation in ATP binding pocket
3
Q
can overcome imatibib resistance
A
dasatinib
4
Q
tx: imatinib
A
CML, GIST
5
Q
tx: basatinib
A
CML, ALL
6
Q
receptors specific for GIST
A
c-kit, PDFR (membrane)
7
Q
tx of imatinib-resistant GIST
A
sunitinib
8
Q
membrane ass’d RTK inhibitors
A
- gefitinib
- erlotinib
- lapatinib
- sunitinib
- sorafenib
9
Q
RTK overexpression seen 25% of breast cancers
A
HER2
10
Q
drugs that inhibit EGFR
A
- gefitinib
- erlotinib
- lapatinib
11
Q
drugs that inhibit HER2
A
lapatinib
12
Q
drugs that inhibit PDFR and VEGFR
A
- sunitinib
- sorafenib
13
Q
tx: gefitinib, erlotinib
A
NSCLC
14
Q
tx: sunitinib
A
- GIST
- RCC
15
Q
tx: sorafenib
A
RCC
HCC
