Pharm Of Skin (continued) Flashcards
Indication for Tretinoin for skin conditions?
acne vulgaris
Decreases cohesion between epidermal cells and increases epidermal cell turnover
Expulsion of open comedones and transforms closed into open ones
ADR of Tretinoin?
teratogenic potential; increased by exposure to sunlight
Adapalene has what advantage over retinoid acid use?
Photochemically stable and less irritating
Indications Isotretinoin?
Severe cystic acne not responding to other topical treatment
Contraindications of Isotretinoin?
pregnant women and women willing to be pregnant
ADR of Isotretinoin?
hypervitaminosis A
Contraindications of isotretinoin?
pseudotumor cerebri, teratogenic
Name a topical corictosteroid used in treatment of psoriasis?
Triamcinolone
MOA topical corticosteroids when treating psoriasis?
Inhibit epidermal cell mitosis effective for psoriasis
Immunosuppressant
Anti inflammatory
ADR topical steroids?
hypopigmentation
allergic contact dermatitis
cig paper skin
steroid acne
Indications calcipotriene and Calcitriol?
plaque type psoriasis vulgaris
Tazarotene indications?
plaque psoriasis
MOA Tazarotene?
anti-inflammatory and anti-proliferative
Indications for Acitretin?
pustular forms of psoriasis
Tar MOA in treatment of psoriasis?
Inhibit excessive skin proliferation and anti inflammatory action.
ADR of TAR compounds?
cosmetically unappealing
Etanercept MOA?
Dimeric fusion protein of extracellular ligand binding portion of the human TNF receptor linked to the Fc portion of IgG
Blocks TNF alpha and beta receptors
What is the MOA of infliximab?
Chimeric IgG
Inhibits TNF alpha binding with its receptors
Adalimumab MOA?
Recombinant IgG blocks TNF alpha binding to its receptors
General toxicity of TNF inhibitors?
Life threatening infections
Reactivation of tuberculosis
Lymphoma
Hydroquinone MOA?
Inhibition of tyrosinase; biosynthesis of melanin
Trioxsalen; methoxsalen indications?
Psoralens – re-pigmentation of depigmented patches of vitiligo
PABA sunscreens and titanium dioxide difference?
PABA absorbs UV light and Titanium reflects ligh
Difference between PABA and benzophenones?
PABA - Absorb UV-B
Benzophenones effective against UVA and UVB wavelength
Minoxidil indications?
androgenic alopecia
MOA finasteride?
Mechanism: 5 alpha reductase inhibitor
Indications of Finasteride?
effective against androgenic alopecia
ADR of Finasteride?
decreased libido, erectile and ejaculatory dysfunction
Bimatoprost MOA?
prostaglandin analogue
Indications of Bimatoprost
increase eye lashes
What is the MOA of Eflornithine agents?
Irreversible inhibitor of ornithine decarboxylase
rate limiting enzyme that catalyzes the rate limiting step for follicular polyamine synthesis, which is necessary for hair growth.
Indication of Eflornithine.
First topical preparation approved by USFDA for the reduction of unwanted facial hair in females
MOA Doxepin?
Mechanism: Inhibitor of H1 and H2 receptors
Indication for Doxepin?
pruritus; esp. in atopic dermatitis & lichen simplex chronicus
What is Doxepin contraindicated in?
Narrow angle glaucoma; urinary retention
What are the indications for Alltretinoin?
cutaneous lesions in AIDS associated Kaposi sarcoma
What are the indications for Bexarotene?
treatment of cutaneous T cell lymphoma
