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SD IV: Block 3 Week 1 > Pharm Of Skin (continued) > Flashcards

Pharm Of Skin (continued) Flashcards

1
Q

Indication for Tretinoin for skin conditions?

A

acne vulgaris

Decreases cohesion between epidermal cells and increases epidermal cell turnover

Expulsion of open comedones and transforms closed into open ones

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2
Q

ADR of Tretinoin?

A

teratogenic potential; increased by exposure to sunlight

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3
Q

Adapalene has what advantage over retinoid acid use?

A

Photochemically stable and less irritating

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4
Q

Indications Isotretinoin?

A

Severe cystic acne not responding to other topical treatment

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5
Q

Contraindications of Isotretinoin?

A

pregnant women and women willing to be pregnant

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6
Q

ADR of Isotretinoin?

A

hypervitaminosis A

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7
Q

Contraindications of isotretinoin?

A

pseudotumor cerebri, teratogenic

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8
Q

Name a topical corictosteroid used in treatment of psoriasis?

A

Triamcinolone

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9
Q

MOA topical corticosteroids when treating psoriasis?

A

Inhibit epidermal cell mitosis effective for psoriasis

Immunosuppressant

Anti inflammatory

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10
Q

ADR topical steroids?

A

hypopigmentation

allergic contact dermatitis

cig paper skin

steroid acne

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11
Q

Indications calcipotriene and Calcitriol?

A

plaque type psoriasis vulgaris

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12
Q

Tazarotene indications?

A

plaque psoriasis

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13
Q

MOA Tazarotene?

A

anti-inflammatory and anti-proliferative

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14
Q

Indications for Acitretin?

A

pustular forms of psoriasis

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15
Q

Tar MOA in treatment of psoriasis?

A

Inhibit excessive skin proliferation and anti inflammatory action.

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16
Q

ADR of TAR compounds?

A

cosmetically unappealing

17
Q

Etanercept MOA?

A

Dimeric fusion protein of extracellular ligand binding portion of the human TNF receptor linked to the Fc portion of IgG

Blocks TNF alpha and beta receptors

18
Q

What is the MOA of infliximab?

A

Chimeric IgG

Inhibits TNF alpha binding with its receptors

19
Q

Adalimumab MOA?

A

Recombinant IgG blocks TNF alpha binding to its receptors

20
Q

General toxicity of TNF inhibitors?

A

Life threatening infections
Reactivation of tuberculosis
Lymphoma

21
Q

Hydroquinone MOA?

A

Inhibition of tyrosinase; biosynthesis of melanin

22
Q

Trioxsalen; methoxsalen indications?

A

Psoralens – re-pigmentation of depigmented patches of vitiligo

23
Q

PABA sunscreens and titanium dioxide difference?

A

PABA absorbs UV light and Titanium reflects ligh

24
Q

Difference between PABA and benzophenones?

A

PABA - Absorb UV-B
Benzophenones effective against UVA and UVB wavelength

25
Q

Minoxidil indications?

A

androgenic alopecia

26
Q

MOA finasteride?

A

Mechanism: 5 alpha reductase inhibitor

27
Q

Indications of Finasteride?

A

effective against androgenic alopecia

28
Q

ADR of Finasteride?

A

decreased libido, erectile and ejaculatory dysfunction

29
Q

Bimatoprost MOA?

A

prostaglandin analogue

30
Q

Indications of Bimatoprost

A

increase eye lashes

31
Q

What is the MOA of Eflornithine agents?

A

Irreversible inhibitor of ornithine decarboxylase

rate limiting enzyme that catalyzes the rate limiting step for follicular polyamine synthesis, which is necessary for hair growth.

32
Q

Indication of Eflornithine.

A

First topical preparation approved by USFDA for the reduction of unwanted facial hair in females

33
Q

MOA Doxepin?

A

Mechanism: Inhibitor of H1 and H2 receptors

34
Q

Indication for Doxepin?

A

pruritus; esp. in atopic dermatitis & lichen simplex chronicus

35
Q

What is Doxepin contraindicated in?

A

Narrow angle glaucoma; urinary retention

36
Q

What are the indications for Alltretinoin?

A

cutaneous lesions in AIDS associated Kaposi sarcoma

37
Q

What are the indications for Bexarotene?

A

treatment of cutaneous T cell lymphoma

SD IV: Block 3 Week 1 (11 decks)

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