Pharm Of Skin (continued)

Question 1

Indication for Tretinoin for skin conditions?

Answer 1

acne vulgaris

Decreases cohesion between epidermal cells and increases epidermal cell turnover

Expulsion of open comedones and transforms closed into open ones

Question 2

ADR of Tretinoin?

Answer 2

teratogenic potential; increased by exposure to sunlight

Question 3

Adapalene has what advantage over retinoid acid use?

Answer 3

Photochemically stable and less irritating

Question 4

Indications Isotretinoin?

Answer 4

Severe cystic acne not responding to other topical treatment

Question 5

Contraindications of Isotretinoin?

Answer 5

pregnant women and women willing to be pregnant

Question 6

ADR of Isotretinoin?

Answer 6

hypervitaminosis A

Question 7

Contraindications of isotretinoin?

Answer 7

pseudotumor cerebri, teratogenic

Question 8

Name a topical corictosteroid used in treatment of psoriasis?

Answer 8

Triamcinolone

Question 9

MOA topical corticosteroids when treating psoriasis?

Answer 9

Inhibit epidermal cell mitosis effective for psoriasis

Immunosuppressant

Anti inflammatory

Question 10

ADR topical steroids?

Answer 10

hypopigmentation

allergic contact dermatitis

cig paper skin

steroid acne

Question 11

Indications calcipotriene and Calcitriol?

Answer 11

plaque type psoriasis vulgaris

Question 12

Tazarotene indications?

Answer 12

plaque psoriasis

Question 13

MOA Tazarotene?

Answer 13

anti-inflammatory and anti-proliferative

Question 14

Indications for Acitretin?

Answer 14

pustular forms of psoriasis

Question 15

Tar MOA in treatment of psoriasis?

Answer 15

Inhibit excessive skin proliferation and anti inflammatory action.

Question 16

ADR of TAR compounds?

Answer 16

cosmetically unappealing

Question 17

Etanercept MOA?

Answer 17

Dimeric fusion protein of extracellular ligand binding portion of the human TNF receptor linked to the Fc portion of IgG

Blocks TNF alpha and beta receptors

Question 18

What is the MOA of infliximab?

Answer 18

Chimeric IgG

Inhibits TNF alpha binding with its receptors

Question 19

Adalimumab MOA?

Answer 19

Recombinant IgG blocks TNF alpha binding to its receptors

Question 20

General toxicity of TNF inhibitors?

Answer 20

Life threatening infections
Reactivation of tuberculosis
Lymphoma

Question 21

Hydroquinone MOA?

Answer 21

Inhibition of tyrosinase; biosynthesis of melanin

Question 22

Trioxsalen; methoxsalen indications?

Answer 22

Psoralens – re-pigmentation of depigmented patches of vitiligo

Question 23

PABA sunscreens and titanium dioxide difference?

Answer 23

PABA absorbs UV light and Titanium reflects ligh

Question 24

Difference between PABA and benzophenones?

Answer 24

PABA - Absorb UV-B
Benzophenones effective against UVA and UVB wavelength

Question 25

Minoxidil indications?

Answer 25

androgenic alopecia

Question 26

MOA finasteride?

Answer 26

Mechanism: 5 alpha reductase inhibitor

Question 27

Indications of Finasteride?

Answer 27

effective against androgenic alopecia

Question 28

ADR of Finasteride?

Answer 28

decreased libido, erectile and ejaculatory dysfunction

Question 29

Bimatoprost MOA?

Answer 29

prostaglandin analogue

Question 30

Indications of Bimatoprost

Answer 30

increase eye lashes

Question 31

What is the MOA of Eflornithine agents?

Answer 31

Irreversible inhibitor of ornithine decarboxylase rate limiting enzyme that catalyzes the rate limiting step for follicular polyamine synthesis, which is necessary for hair growth.

Question 32

Indication of Eflornithine.

Answer 32

First topical preparation approved by USFDA for the reduction of unwanted facial hair in females

Question 33

MOA Doxepin?

Answer 33

Mechanism: Inhibitor of H1 and H2 receptors

Question 34

Indication for Doxepin?

Answer 34

pruritus; esp. in atopic dermatitis & lichen simplex chronicus

Question 35

What is Doxepin contraindicated in?

Answer 35

Narrow angle glaucoma; urinary retention

Question 36

What are the indications for Alltretinoin?

Answer 36

cutaneous lesions in AIDS associated Kaposi sarcoma

Question 37

What are the indications for Bexarotene?

Answer 37

treatment of cutaneous T cell lymphoma