Pharm Of Skin (continued) Flashcards

1
Q

Indication for Tretinoin for skin conditions?

A

acne vulgaris

Decreases cohesion between epidermal cells and increases epidermal cell turnover

Expulsion of open comedones and transforms closed into open ones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ADR of Tretinoin?

A

teratogenic potential; increased by exposure to sunlight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Adapalene has what advantage over retinoid acid use?

A

Photochemically stable and less irritating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Indications Isotretinoin?

A

Severe cystic acne not responding to other topical treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Contraindications of Isotretinoin?

A

pregnant women and women willing to be pregnant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ADR of Isotretinoin?

A

hypervitaminosis A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Contraindications of isotretinoin?

A

pseudotumor cerebri, teratogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name a topical corictosteroid used in treatment of psoriasis?

A

Triamcinolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA topical corticosteroids when treating psoriasis?

A

Inhibit epidermal cell mitosis effective for psoriasis

Immunosuppressant

Anti inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ADR topical steroids?

A

hypopigmentation

allergic contact dermatitis

cig paper skin

steroid acne

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Indications calcipotriene and Calcitriol?

A

plaque type psoriasis vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tazarotene indications?

A

plaque psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MOA Tazarotene?

A

anti-inflammatory and anti-proliferative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Indications for Acitretin?

A

pustular forms of psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tar MOA in treatment of psoriasis?

A

Inhibit excessive skin proliferation and anti inflammatory action.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ADR of TAR compounds?

A

cosmetically unappealing

17
Q

Etanercept MOA?

A

Dimeric fusion protein of extracellular ligand binding portion of the human TNF receptor linked to the Fc portion of IgG

Blocks TNF alpha and beta receptors

18
Q

What is the MOA of infliximab?

A

Chimeric IgG

Inhibits TNF alpha binding with its receptors

19
Q

Adalimumab MOA?

A

Recombinant IgG blocks TNF alpha binding to its receptors

20
Q

General toxicity of TNF inhibitors?

A

Life threatening infections
Reactivation of tuberculosis
Lymphoma

21
Q

Hydroquinone MOA?

A

Inhibition of tyrosinase; biosynthesis of melanin

22
Q

Trioxsalen; methoxsalen indications?

A

Psoralens – re-pigmentation of depigmented patches of vitiligo

23
Q

PABA sunscreens and titanium dioxide difference?

A

PABA absorbs UV light and Titanium reflects ligh

24
Q

Difference between PABA and benzophenones?

A

PABA - Absorb UV-B
Benzophenones effective against UVA and UVB wavelength

25
Minoxidil indications?
androgenic alopecia
26
MOA finasteride?
Mechanism: 5 alpha reductase inhibitor
27
Indications of Finasteride?
effective against androgenic alopecia
28
ADR of Finasteride?
decreased libido, erectile and ejaculatory dysfunction
29
Bimatoprost MOA?
prostaglandin analogue
30
Indications of Bimatoprost
increase eye lashes
31
What is the MOA of Eflornithine agents?
Irreversible inhibitor of ornithine decarboxylase rate limiting enzyme that catalyzes the rate limiting step for follicular polyamine synthesis, which is necessary for hair growth.
32
Indication of Eflornithine.
First topical preparation approved by USFDA for the reduction of unwanted facial hair in females
33
MOA Doxepin?
Mechanism: Inhibitor of H1 and H2 receptors
34
Indication for Doxepin?
pruritus; esp. in atopic dermatitis & lichen simplex chronicus
35
What is Doxepin contraindicated in?
Narrow angle glaucoma; urinary retention
36
What are the indications for Alltretinoin?
cutaneous lesions in AIDS associated Kaposi sarcoma
37
What are the indications for Bexarotene?
treatment of cutaneous T cell lymphoma