Dermatopathology 02 Flashcards

1
Q

Excoriation

A

traumatic lesion breaking the epidermis and causing a raw linear area (.3., deep scratch); often self-induced

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2
Q

Lichenification

A

Thickened, rough skin (similar to a lichen on a rock); usually the result of repeated rubbing

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3
Q

Macule, Patch

A

Circumscribed, flat lesion distinguished from surrounding skin by color. Macules are 5 mm in diameter or less, patches are greater than 5 mm.

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4
Q

Onycholysis

A

separation of nail plate from nail bed

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5
Q

Papule, Nodule

A

elected dome-shaped or flat topped lesion. Papules are 5 mm or less across, while nodules are greater than 5 mm in size.

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6
Q

Plaque

A

Elevated flat-topped lesion, usually greater than 5 mm across (may be caused by coalescent papules)

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7
Q

Pustule

A

Discrete, pus-filled, raised lesion

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8
Q

Scale

A

Dry, horny, platelike excrescence; usually the result of imperfect cornification

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9
Q

Vesicle, Bulla, Blister

A

Fluid-filled raised lesion 5 mm or less across (vesicle) or greater than 5 mm across (bulla). Blister is the common term for either.

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10
Q

Wheal

A

Itchy, transient, elevated lesion with variable blanching and erythema formed as the result of dermal edema

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11
Q

Compare macules, papules, and nodules.

A

Macules are pigmented or erythematous flat lesions on the epidermis while

Papules are peaked or dome-shaped (surface elevation <5mm in diameter )

Nodules elevated dome shaped lesion (>5mm in diameter)

The size is what sets papules and nodules apart Macules are flat lesions and distinguishable from surrounding skin color.

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12
Q

Acanthosis

A

diffuse epidermal hyperplasia

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13
Q

Dyskeratosis

A

Abnormal, premature keratinization within cells below the stratum granulosum

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14
Q

Erosion

A

Discontinuity of the skin showing incomplete loss of epidermis

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15
Q

Exocytosis

A

Infiltration of the epidermis by inflammatory cells

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16
Q

Hydronic swelling (ballooning).

A

Intracellular edema of keratinocytes, often seen in viral infections

17
Q

Hypergranulosis

A

Hyperplasia of the stratum granulosujm, often due to intense rubbing

18
Q

Hyperkeratosis

A

Thickening of the stratum corneum, often associated with a qualitative abnormality of he keratin

19
Q

Lentiginous

A

A linear pattern of melanocyte proliferation within the epidermal basal cell layer

20
Q

Papillomatosis

A

Surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae

21
Q

Parakeratosis

A

keratinization with retained nuclei in the stratum corneum. On mucous membranes, parakeratosis is normal

22
Q

Spongiosis

A

intercellular edema of the epidermis

23
Q

Ulceration

A

Discontinuity of the skin showing complete loss of the epidermis revealing dermis or subcutis

24
Q

Vacuolization

A

formation of vacuoles within or adjacent to cells; often refers to basal cell-basement membrane zone area

25
How do you perform a SPT?
skin prick test Should be first test to determine allergy sensitivity Both major and minor determinants are used A sterile needle injects patient with allergen then wait 15-20 min to read. A positive test is when the wheal size ≥ 3 mm than negative control
26
What is a skin prick test?
most sensitive test for allergies
27
How do you perform an intradermal skin test?
Performed only if skin prick test is negative May induce systemic rxns Its more sensitive than a skin prick test Positive when wheal size is ≥ 4 mm than control
28
What is being seen in both images and what is the condition?
On left Auzpitz sign and silvery scales on psoriatic patient ON right Monroe abscesses
29
What is being seen in this image and what is the diagnosis?
On left Auzpitz sign and silvery scales On right Munroe Abscesses psoriatic patient
30
What is being seen in this image and what is the suspected condition?
spongiform pustules of Kogoj Psoriasis
31
What is the condition being seen in this image?
Ichtyhyosis