Dermatopathology 02

Question 1

Excoriation

Answer 1

traumatic lesion breaking the epidermis and causing a raw linear area (.3., deep scratch); often self-induced

Question 2

Lichenification

Answer 2

Thickened, rough skin (similar to a lichen on a rock); usually the result of repeated rubbing

Question 3

Macule, Patch

Answer 3

Circumscribed, flat lesion distinguished from surrounding skin by color. Macules are 5 mm in diameter or less, patches are greater than 5 mm.

Question 4

Onycholysis

Answer 4

separation of nail plate from nail bed

Question 5

Papule, Nodule

Answer 5

elected dome-shaped or flat topped lesion. Papules are 5 mm or less across, while nodules are greater than 5 mm in size.

Question 6

Plaque

Answer 6

Elevated flat-topped lesion, usually greater than 5 mm across (may be caused by coalescent papules)

Question 7

Pustule

Answer 7

Discrete, pus-filled, raised lesion

Question 8

Scale

Answer 8

Dry, horny, platelike excrescence; usually the result of imperfect cornification

Question 9

Vesicle, Bulla, Blister

Answer 9

Fluid-filled raised lesion 5 mm or less across (vesicle) or greater than 5 mm across (bulla). Blister is the common term for either.

Question 10

Wheal

Answer 10

Itchy, transient, elevated lesion with variable blanching and erythema formed as the result of dermal edema

Question 11

Compare macules, papules, and nodules.

Answer 11

Macules are pigmented or erythematous flat lesions on the epidermis while

Papules are peaked or dome-shaped (surface elevation <5mm in diameter )

Nodules elevated dome shaped lesion (>5mm in diameter)

The size is what sets papules and nodules apart Macules are flat lesions and distinguishable from surrounding skin color.

Question 12

Acanthosis

Answer 12

diffuse epidermal hyperplasia

Question 13

Dyskeratosis

Answer 13

Abnormal, premature keratinization within cells below the stratum granulosum

Question 14

Erosion

Answer 14

Discontinuity of the skin showing incomplete loss of epidermis

Question 15

Exocytosis

Answer 15

Infiltration of the epidermis by inflammatory cells

Question 16

Hydronic swelling (ballooning).

Answer 16

Intracellular edema of keratinocytes, often seen in viral infections

Question 17

Hypergranulosis

Answer 17

Hyperplasia of the stratum granulosujm, often due to intense rubbing

Question 18

Hyperkeratosis

Answer 18

Thickening of the stratum corneum, often associated with a qualitative abnormality of he keratin

Question 19

Lentiginous

Answer 19

A linear pattern of melanocyte proliferation within the epidermal basal cell layer

Question 20

Papillomatosis

Answer 20

Surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae

Question 21

Parakeratosis

Answer 21

keratinization with retained nuclei in the stratum corneum. On mucous membranes, parakeratosis is normal

Question 22

Spongiosis

Answer 22

intercellular edema of the epidermis

Question 23

Ulceration

Answer 23

Discontinuity of the skin showing complete loss of the epidermis revealing dermis or subcutis

Question 24

Vacuolization

Answer 24

formation of vacuoles within or adjacent to cells; often refers to basal cell-basement membrane zone area

Question 25

How do you perform a SPT?

Answer 25

skin prick test

Should be first test to determine allergy sensitivity

Both major and minor determinants are used

A sterile needle injects patient with allergen then wait 15-20 min to read.

A positive test is when the wheal size ≥ 3 mm than negative control

Question 26

What is a skin prick test?

Answer 26

most sensitive test for allergies

Question 27

How do you perform an intradermal skin test?

Answer 27

Performed only if skin prick test is negative

May induce systemic rxns

Its more sensitive than a skin prick test

Positive when wheal size is ≥ 4 mm than control

Question 28

What is being seen in both images and what is the condition?

Answer 28

On left Auzpitz sign and silvery scales on psoriatic patient
ON right Monroe abscesses

Question 29

What is being seen in this image and what is the diagnosis?

Answer 29

On left Auzpitz sign and silvery scales
On right Munroe Abscesses

psoriatic patient

Question 30

What is being seen in this image and what is the suspected condition?

Answer 30

spongiform pustules of Kogoj

Psoriasis

Question 31

What is the condition being seen in this image?

Answer 31

Ichtyhyosis