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SD IV: Block 3 Week 1 > Pharm of Skin > Flashcards

Pharm of Skin Flashcards

1
Q

What are some topical antibiotics used for acne?

A

clindamycin, erythromycin, metronidazole, sodium sulfacetamide, dapsone

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2
Q

What type of drug is Bacitracin and Gramcidin?

A

antibacterials/peptide antibiotics

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3
Q

What type of bacteria is bacitracin and Gramcidin useful against?

A

Gram - bacteria

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4
Q

What are the indications for Bacitracin and Gramcidin?

A

Eradicate pathogenic Staph from anterior nares

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5
Q

Complications Bacitracin and Gramcidin?

A

Contact dermatitis

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6
Q

Bacitracin and Gramcidin can be used as a triple antibiotic with which drug?

A

Neomycin and Polymyxin B

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7
Q

What type of drug is Polymyxin B?

A

Anti-bacterial/peptide antibiotic

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8
Q

What types of bacteria is Polymyxin B useful against?

A

Gram -

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9
Q

Complications Poly B?

A

neurotoxicity/nephrotoxicity

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10
Q

Neomycin and Gentamicin are effective against what type of bacteria?

A

Gram -ve

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11
Q

Mupirocin indications??

A

impetigo by Staph aureus or Group A beta -hemolytic Strep

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12
Q

What type of bacteria is Mupirocin (pseudominic acid A) useful against?

A

gram positive aerobic, including MRSA

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13
Q

MOA sodium sulfacetamide in treatment of acne?

A

inhibition of p.acnes by competitive inhibition of PABA.

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14
Q

What are contraindications of Dapsone use?

A

Contraindicated in G6PD deficiency, methemoglobinemia

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15
Q

What are the indications for topical azoles?

A

Dermatophytic fungal infections of the skin and Candidal infections

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16
Q

Indications for ciclopirox Lamine?

A

Active against dermatophytes and candida species

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17
Q

MOA of Allylamines?

A

Inhibit squalene epoxidase - first step in synthesis of ergosterol

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18
Q

Name the Allymines?

A

Terbinafine
Naftifine

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19
Q

What is MOA of Butenafine?

A

Inhibit squalene epoxidase - first step in synthesis of ergosterol

20
Q

Nystatin and Amphotericin B MOA?

A

Binds to fungal ergosterol and creates pores in fungal cell membrane

21
Q

Indications for Nystatin and Amphotericin B?

A

Mouth washes for oral candidiasis
Also useful for vaginal, vulvar, perianal candidiasis and diaper rash.

22
Q

Uses of Itraconazole and fluconazole?

A

treatment of dermatophytes and yeast infection

onychomycosis

23
Q

A/E of Itraconazole?

A

ventricular dysfunction

24
Q

Drug-Drug interaction of Itraconazole, fluconazole?

A

co-admin with statins result in higher risk of rhabdomyolysis

25
Q

Griseofulvin indications?

A

Active against dermatophyte infection of scalp and nails

26
Q

S/E of griseofulvin?

A

Nausea, vomiting, photosensitivity, peripheral neuritis and confusion

penicillin cross sensitivity

disulfiram effect

27
Q

Terbinafine indications?

A

onychomycosis

28
Q

Terbinafine indications?

A

onychomycosis

29
Q

MOA terbineafine?

A

Inhbitis lanesterol synthesis

30
Q

Use of the topical anti viral agents? Acyclovir (all the clovirs)

A

Orolabial herpes

31
Q

MOA Foscarnet

A

Inhibits viral RNA polymerase, DNA polymerase and HIV reverse transcriptase.

32
Q

Indication Imiquimod.

A

External genital and perianal warts
Actinic keratosis

33
Q

MOA of Imiquimod?

A

stimulates peripheral mononuclear cells to release IFN-α and macrophages to produce IL-1, 6, 8 and TNF- α

34
Q

MOA Dupilumab?

A

IL-4α antagonist

35
Q

Indications of Dupilumab?

A

moderate to severe atopic dermatitis

36
Q

What are the indications of Tacrolimus and Pimecrolimus?

A

atopic dermatitis

37
Q

MOA Tacrolimus?

A

T-lymphocyte activation and prevent release of inflammatory cytokines

38
Q

ADR of Tacrolimus and Pimecrolimus.

A

burning sensation in the applied area

39
Q

Ectoparasiticides are typically indicated for what?

A

Treatment of scabies and pediculosis

40
Q

Indications Permethrin?

A

Most efficacious and most convenient drug for both lice and scabies

41
Q

A/E of Permetrhin

A

transient burning, tingling, itching

42
Q

Indications for Ivermectin?

A

pediculosis

43
Q

A/E of Lindane?

A

Neurotoxicity and hematotoxicity in children, new born and pregnant

44
Q

MOA Crisaborole.

A

Non-steroidal topical anti-inflammatory PDE-4 inhibitor

45
Q

Indication Crisaborole?

A

mild-to moderate atopic dermatitis

46
Q

ADR Crisaborole?

A

burning or stinging at the site of application

SD IV: Block 3 Week 1 (11 decks)

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