Pharm Of Schizophrenia Flashcards
Typical (conventional or first gen ) anti psychotics target which symptoms
Positive symptoms
What receptor antagonist is typical first gen antipsychotics
Dopamine d2 receptor antagonist
What are you greater at risk for with typical antipsychotics
EPS symptoms
Atypical second gen antipsychotics target
Positive and negative symptoms
Antagonist of Atypical meds
Serotonin -dopamine antagonist
What are atypical meds at increase risk for
Metabolic syndrom
What is an issue with having access to second gen antipsychotics
More costly
Typical (FGA)
Haloperidol
Chlorpromazine
Trifluoperazine
Thiothixene
Fluphenazine
Thiothixene
Loxapine
Perphenazine
Black box warning for typical FGA
Not approved for dementia related psychosis
FGA side effects
Anticholinergic effects
Weight gain
Sexual/reproductive organ issues
Increased prolactin levels
Seizures
Sedation
Agranulocytosis
NMS
Cardiac events EPS*
Drug induced liver disease
Agranulocytosis
Decrease in WBC
EPS
Akathisia
Pseudoparkinosism
Acute dystonia
Tardive dyskinesia
Torticolus
Neck .. important to treat to avoid choking
How do we treat acute dystonia
Give IM Benadryl because they can’t take anything orally
Tardive dyskinesia
Serous and irreversible
Involuntary tonic muscle spasms , involving face , lips , tongues , trunk and extremities
When may TD subside
After meds are discontinued but may be permanent
Anticholinergic effect
Red as a beet
Dry as a bone
Blind as a bat
Hot as a hare
Full as a flask
Atypical 2nd gen antipsychotics
Clozapine
Risperdone
Olanzapine
Quetiapine
Ziprasidone
Paliperdone
Lurasidone
Iloperidone
Cariprazine
Aripiprazole
What two meds cause weight gain in the atypical
Olanzapine and clozapine
What two atypical med can cause weight loss
Ziprasidone and aripipazole
Long acting psychotics
Haloperidol decanoate
Fluphenazine decanoate
Risperadone
Paliperidone palmitate
Olanzapine palmate
Paliperidone palmitate
Invega sustenna
Why would these medications long acting antipsychotics be given?
If they aren’t compliant
They dont have to worry about getting to appointments to receive it but at least not daily basis
Antiparkinsons drugs ( treatment of EPS)
Trihexyphenidyl
Benztropine
Diphenhydramine
Biperiden
