Pharm Of Schizophrenia Flashcards
Typical (conventional or first gen ) anti psychotics target which symptoms
Positive symptoms
What receptor antagonist is typical first gen antipsychotics
Dopamine d2 receptor antagonist
What are you greater at risk for with typical antipsychotics
EPS symptoms
Atypical second gen antipsychotics target
Positive and negative symptoms
Antagonist of Atypical meds
Serotonin -dopamine antagonist
What are atypical meds at increase risk for
Metabolic syndrom
What is an issue with having access to second gen antipsychotics
More costly
Typical (FGA)
Haloperidol
Chlorpromazine
Trifluoperazine
Thiothixene
Fluphenazine
Thiothixene
Loxapine
Perphenazine
Black box warning for typical FGA
Not approved for dementia related psychosis
FGA side effects
Anticholinergic effects
Weight gain
Sexual/reproductive organ issues
Increased prolactin levels
Seizures
Sedation
Agranulocytosis
NMS
Cardiac events EPS*
Drug induced liver disease
Agranulocytosis
Decrease in WBC
EPS
Akathisia
Pseudoparkinosism
Acute dystonia
Tardive dyskinesia
Torticolus
Neck .. important to treat to avoid choking
How do we treat acute dystonia
Give IM Benadryl because they can’t take anything orally
Tardive dyskinesia
Serous and irreversible
Involuntary tonic muscle spasms , involving face , lips , tongues , trunk and extremities