Pharm Of Schizophrenia Flashcards

1
Q

Typical (conventional or first gen ) anti psychotics target which symptoms

A

Positive symptoms

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2
Q

What receptor antagonist is typical first gen antipsychotics

A

Dopamine d2 receptor antagonist

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3
Q

What are you greater at risk for with typical antipsychotics

A

EPS symptoms

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4
Q

Atypical second gen antipsychotics target

A

Positive and negative symptoms

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5
Q

Antagonist of Atypical meds

A

Serotonin -dopamine antagonist

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6
Q

What are atypical meds at increase risk for

A

Metabolic syndrom

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7
Q

What is an issue with having access to second gen antipsychotics

A

More costly

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8
Q

Typical (FGA)

A

Haloperidol
Chlorpromazine
Trifluoperazine
Thiothixene
Fluphenazine
Thiothixene
Loxapine
Perphenazine

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9
Q

Black box warning for typical FGA

A

Not approved for dementia related psychosis

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10
Q

FGA side effects

A

Anticholinergic effects
Weight gain
Sexual/reproductive organ issues
Increased prolactin levels
Seizures
Sedation
Agranulocytosis
NMS
Cardiac events EPS*
Drug induced liver disease

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11
Q

Agranulocytosis

A

Decrease in WBC

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12
Q

EPS

A

Akathisia
Pseudoparkinosism
Acute dystonia

Tardive dyskinesia

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13
Q

Torticolus

A

Neck .. important to treat to avoid choking

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14
Q

How do we treat acute dystonia

A

Give IM Benadryl because they can’t take anything orally

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15
Q

Tardive dyskinesia

A

Serous and irreversible

Involuntary tonic muscle spasms , involving face , lips , tongues , trunk and extremities

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16
Q

When may TD subside

A

After meds are discontinued but may be permanent

17
Q

Anticholinergic effect

A

Red as a beet
Dry as a bone
Blind as a bat
Hot as a hare
Full as a flask

18
Q

Atypical 2nd gen antipsychotics

A

Clozapine
Risperdone
Olanzapine
Quetiapine
Ziprasidone
Paliperdone
Lurasidone
Iloperidone
Cariprazine
Aripiprazole

19
Q

What two meds cause weight gain in the atypical

A

Olanzapine and clozapine

20
Q

What two atypical med can cause weight loss

A

Ziprasidone and aripipazole

21
Q

Long acting psychotics

A

Haloperidol decanoate
Fluphenazine decanoate
Risperadone
Paliperidone palmitate
Olanzapine palmate

22
Q

Paliperidone palmitate

A

Invega sustenna

23
Q

Why would these medications long acting antipsychotics be given?

A

If they aren’t compliant
They dont have to worry about getting to appointments to receive it but at least not daily basis

24
Q

Antiparkinsons drugs ( treatment of EPS)

A

Trihexyphenidyl
Benztropine
Diphenhydramine
Biperiden

25
Q

2 most commonly used antiparkisons drugs

A

Benztropine
Diphenhydramine

26
Q

Abrupt onset with good premorbid functioning of schizophrenia has

A

Better prognosis and greater chance of remission and complete recovery