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Repro II > pharm of prego > Flashcards

pharm of prego Flashcards

1
Q

drug transfer across placenta

A

dependent upon lipid solubility and polarity

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2
Q

thiopental

A

barbituate used in C-sections

rapdily crosses placenta

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3
Q

succinylcholine and tubocurarine

A

used in C-sections

highly charged and cross placenta slowly

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4
Q

heparin

A

safe togive in prego

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5
Q

warfarin

A

crosses placenta and is teratogenic

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6
Q

what tissues can be effected by drugs differently during prego

A

repro- breast and uterus

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7
Q

what tissues are not effected differently during prego?

A

heart
lungs
kidneys
CNS

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8
Q

examples of fetal Rx

A

corticosteroids to stimulate lungs
antiarrhythmics
zidovudine to prevent HIV transmission

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9
Q

diethylstillbestol

A

increased risk for adenocarcinoma when child get to puberty

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10
Q

teratogen characteristics

A

drug use results in characteristic set of malformations
exerts effects at particular stage of fetal development
dose-dependent incidence

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11
Q

antiemetics

A 
pyridoxine 
antihistamines
dopamine antagonists
serotonin antagonisits
glucocortiocoids
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12
Q

pyridoxine

A

vit B6

precursor to pyridoxal increases GABA synthesis

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13
Q

antihistamines

A

anticholinergic activity

doxylamine most common used in combo with pyridoxine

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14
Q

when do you Tx preeclampsia with antiHTN

A

> 150/100

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15
Q

antiHTNs for preeclampsia

A

labetalol
hydralazine (aa not vv)
nifedipine and nicardipinde (block LCaChs

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16
Q

what should NOT be used to Tx HTN in prego

A

ACE inhibitors
angiotensin R blockers
direct renin inhibitors

17
Q

what should be used to Tx preexisitng HTN

A

labetalol
methyldopa
nifedipine
thiazide diuretics

18
Q

thiazide diuretics ADR

A

hypokalemic metabolic alkalosis
hyperglycemia
hyperlipidemia
hyponatremia

19
Q

Tx of GDB

A

insulin

lispro and aspart

20
Q

tocolytics

A

beta agonists
magnesium sulfate
CaCh blockers
COX inhibitors

21
Q

beta agonists

A

tachyphylaxis
ritodrine most commonly used
many adverse effects - tachy, low BP, bronchial relaxation

22
Q

magnesium sulfate

A

unknown MOA- possibly interferes with mysoin light-chain kinase
few adverse effects (diaphoresis and flushing)
CI in MG

23
Q

CCBs

A

questionable safety

24
Q

COX inhibitors

A

Indomethacin most commonly used
reduced PGs
primary fetal concerns is constriction of ductus arteriosus and oligohydramnios

25
Q

induction of labor

A

oxytocin

vaginal PGs

26
Q

oxytocin MOA

A

sitmulates uterine mm contraction via Gq -> stimualtes release of PGs and leukotrienes
also causes milk ejection

27
Q

opioids

A

does cross placenta dn decreased FHR and respirations

28
Q

neuroaxial analgesics

A

spinals and epidurals

Repro II (20 decks)

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