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Repro II > male physio review > Flashcards

male physio review Flashcards

1
Q

klinefelters

A

XXY

seminiferous tubule dysgenesis

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2
Q

What promotes intrauterine development of testes

A

SRY gene on Y chrom

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3
Q

what produces AMH

A

sertoli cells

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4
Q

what produces T

A

leydig cells

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5
Q

what hormone stimulates fetal leydig cell production of T before LH is produced?

A

hCG

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6
Q

what can be used to stimulate spermatogenesis in oligospermic men

A

hCG

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7
Q

what is required for development of other male organs and secondary sex characteristics?

A

DHT

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8
Q

what enzyme is required for conversion of T -> DHT

A

5alpha-reductase-2

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9
Q

6-8 weeks gestataion

A

differentiation of testes (SRY)

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10
Q

wk 8 gestation

A

retention of wolffian ducts d/t T and regression of mullerian ducts d/t AMH

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11
Q

wk 9-12 gestation

A

male type external genitalia d/t DHT

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12
Q

what enzyme converts androgen to estrogen

A

CYP19-aromatase

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13
Q

what hormone initiates puberty?

A

pulsatile sleep associated release of GnRH

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14
Q

primary hypogonadism labs

A

gonadotropin levels elevated

androgen production is reduced

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15
Q

androgenic actions of androgens

A
  • differentiation of male internal T and external genitalia DHT in fetus
  • growth, development of secondary sex characteristics at puberty
  • maintenance of reproductive tract and production of semen
  • initiation and maintenance of spermatogenesis
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16
Q

anabolic actions of androgens

A
  • stimulation of erythropoietin synthesis
  • stimulation of sebaceous gland secretion
  • control of protein anabolic effects (N retention)
  • stimulation of linear body growth, bone growth, and closure of epiphyses
  • promotion of ABP synthesis
  • maintenance of secretions of sex glands
  • regulation of behavioral effects, libido
17
Q

what protein is responsible for maintaining T concentration in testes

A

ABP

androgen binding protein

18
Q

how much T is required for spermatogenesii

A

100x > circulating levels

19
Q

what cells are the target of LH

A

leydig

20
Q

what cells are target of FSH

A

sertoli

21
Q

GnRH therapy

A

can be used to Tx prostate CA

if given continuously supresses LH and FSH production therefore decreases T

22
Q

supportive fnx of sertoli cells

A

maintaining testes-blood barrier
phagocytosis
nutrients for sperm
R for hormones and paracrines

23
Q

exocrine fnx of sertoli cells

A

fluid produced for sperm mobilization
production of ABP
spermination (release of sperm into tubule)

24
Q

endocrine fnx of sertoli cells

A

expression of T, ABP, and FSH Rs

production of AMH, aromatase, and inhibin B

Repro II (20 decks)

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