Pharm- Ischemia

Question 1

Nitrates- Use

Answer 1

• first line for immediate reliefe of angina

- can be used for effort induced angina 2-5 min before activity

Question 2

Nitrates- Effects on O2

Answer 2

Reduction of NO to cause relaxation of cardiac muscle

- Stops influx of calcium

Question 3

Nitrates- Effect

Answer 3

• Venous dilation
• decrease load, wall stress,
• increased delivery

Question 4

Beta blockers- Use

Answer 4

• First line agents for chronic , stable angina
• Decrease diastole to improve ischemic events
• Increased exercise tolerance

Question 5

Beta blockers- Effects of O2

Answer 5

• Cardio selective: block beta receptors in heart muscle, sympathetic activity, decreasing time in diastole

Question 6

Ca Channel blockers- Use

Answer 6

• When beta blockers contraindicated or SE unacceptable
• Prevents further progression of disease
• First line for vasospastic angina

Question 7

Ca Channel blockers- Effects on O2

Answer 7

• Decrease HR, contractility
• Increase coronary vasodilation
• Decrease BP- Increase coronary blood flow