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Pharm Drug SFx (from DIT) Flashcards

1
Q

Cardiovascular SFx

A

Flushing, coronary vasospasm, torsades de pointes

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2
Q

Blood disorder SFx

A

Thrombocytopenia, agranulocytosis, aplastic anemia, gray baby syndrome, hemolysis in G6PD deficiency, thrombosis

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3
Q

Respiratory SFx

A

Pulmonary fibrosis, cough

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4
Q

GI SFx

A

Pseudomembranous colitis, hepatic necrosis, hepatitis, tertiary adrenal insufficiency

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5
Q

Endocrine SFx

A

Gynocomastia, hot flashes, hypothyroidism

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6
Q

MSK SFx

A

Gout, gingival hyperplasia, osteoporosis, photosensitivity, Stevens-Johnson syndrome, drug-induced lupus, tendinitis/cartilage damage

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7
Q

Renal SFx

A

Interstitial nephritis, diabetes insipidus, Fanconi syndrome, hemorrhagic cystitis

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8
Q

Neuro SFx

A

Parkinson-like syndrome, cinchonism, seizures, tardive dyskinesia

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9
Q

Multi-organ SFx

A

Disulfiram-like reaction, nephrotoxicity + neurotoxicity, nephrotoxicity + ototoxicity, anticholinergic effects

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10
Q

SFx - flushing

A

vancomycin (red man syndrome)
niacin
adenosine
Dihydropyridine calcium channel blockers

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11
Q

SFx - coronary vasospasm

A

cocaine
amphetamines
-triptans
ergotamine

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12
Q

SFx - dilated cardiomyopathy

A

anti-CA drugs: (+ bone marrow suppression)
doxorubicin
daunorubicin

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13
Q

SFx - torsades de pointes

A 
potassium channel blockers (class III)
sodium channel blockers (class IA)
macrolides
haloperidol
chloroquine
protease inhibitors (HIV)
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14
Q

SFx - thrombocytopenia

A

heparin (HIT)

cimetidine (H2 blocker)

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15
Q

SFx - agranulocytosis (the 3 C’s)

A

clozapine, carbamazepine, colchicine
propylthiouracil (PTU), methimazole (anti-thyroid)
dapsone

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16
Q

SFx - aplastic anemia

A 
chloramphenicol
benzene
NSAIDs
propulthiouracil (PTU)
methimazole
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17
Q

SFx - gray baby syndrome

A

Sx: cyanosis, CV issues

chloramphenicol (inactivates UGT)

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18
Q

SFx - hemolysis in G6PD deficiency

A 
isoniazid
sulfonamides
primaquine
ASA (high-dose)
ibuprofen
nitrofurantoin (tx UTI)
dapsone
fava beans
naphthalene
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19
Q

SFx - thrombosis

A

oral contraceptives (esp: smoker, F, over 35yo, on OCPs)

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20
Q

SFx - pulmonary fibrosis

A

amiodarone (tx afib - labs: LFTs, PFTs, TFTs)
bleomycin
busulfan

21
Q

SFx - cough

A 
ACE inhibitors (via inc bradykinin)
(sub ARBIs = no cough)
22
Q

SFx - pseudomembranous colitis

A

clindamycin

amoxicillin/ampicillin

23
Q

SFx - hepatic necrosis

A

halothane
acetaminophen
valproic acid
amanita phalloides

24
Q

SFx - hepatitis

A

isoniazid (P450 inhibitor)

25
Q

SFx - tertiary adrenal insufficiency

A

corticosteroid withdrawal (asthma, RA, OA)

26
Q

SFx - gynecomastia “STACKED knockers”

A 
Spironolactone*****
THC (marijuana)
Alcohol (chronic use)
Cimetidine
Ketoconazole*******
Estrogens
Digoxin
Note - if it causes gynocomastia, likely is anti-androgen (ex: keto, spironolactone)
27
Q

SFx - hot flashes

A

tamoxifen, clomiphene (selective Estrogen R modulator)

28
Q

SFx - hypothyroidism

A

amiodarone, lithium, sulfonamides

29
Q

SFx - gout (right 1st toe)

A

diuretics (loop and thiazide)
niacin (tx low HDL)
cyclosporine
pyrazinamide

30
Q

SFx - gingival hyperplasia

A

phenytoin

verapamil

31
Q

SFx - osteoporosis

A

corticosteroids

heparin

32
Q

SFx - photosensitivity “SAT for photo”

A

Sulfonamides
Amiodarone
Tetracycline

33
Q

SFx - Stevens-Johnson syndrome “CLAPPPERS”

A 
Carbamazepine*
Lamotrigine*
Allopurinol
Phenytoin*
Phenobarbital*
Penicillin
Ethosuximide*
RASH (sx no rx)
Sulfa drugs
*indicate seizure drugs
34
Q

SFx - drug-induced lupus “SHIPP”

A 
Sulfonamides
Hydralazine
Isoniazid
Procainamide
Phenytoin
35
Q

SFx - tendinitis/cartilage damage

A

fluoroquinolones

36
Q

SFx - interstitial nephritis

A

NSAIDs
furosemide
antibiotics

37
Q

SFx - diabetes insipidus

A

lithium
demeclocycline
(tx with amiloride or HCTZ)

38
Q

SFx - Fanconi syndrome (proximal tubular defect)

A

tetracycline (expired)

*also caused by heavy metal exposure, Wilson Dz

39
Q

SFx - hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

40
Q

SFx - parkinsonian-like syndrome

A

metoclopramide (tx gastric emptying Ds)
antipsychotics
reserpine (NE packaging blocker)

41
Q

SFx - cinchonism (dizziness, headache, vision changes, tinnitus)

A

quinidine

quinine

42
Q

SFx - seizures

A 
bupropion
imipenem/cilastatin
isoniazid
tramadol
metoclopramide
benzodiazepine/alcohol withdrawal
43
Q

SFx - tardive dyskinesia

A

antipsychotics

metoclopramide

44
Q

SFx - disulfram-like reaction

A 
metronidazole
certain cephalosporins
procarbazine
first-gen sulfonylureas
disulfram
45
Q

SFx - nephrotoxicity + neurotoxicity

A

aminoglycosides
cisplatin
polymixins

46
Q

SFx - nephrotoxicity + ototoxicity

A

aminoglycosides
vancomycin
loop diuretics
cisplatin

47
Q

SFx - anticholinergic effects

A

atropine
TCAs
H1 blockers (diphenhydramine)
low-potency neuroleptics (thioridazine, chlorpromazine)
(*don’t give anti-chol to patients with urinary issues, dementia, BPH)

48
Q

SFx - Acute Interstitial Nephritis “Drug induced Nephritis”

A 
Abx:
Penecillins, Cephalosporins
Ciprofloxacin
Rifampin
Sulfonamides
\\
NSAIDs
Diurretics
Proton Pump Inhibitors
Cimetidine
Allopurinol

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