First Aid - Oncogens and Tumor Suppessor Genes Flashcards
1
Q
ALK
A
Receptor tyrosine kinase
–Lung adenocarcinoma
2
Q
BCR-ABL
A
Tyrosine kinase
– CML, ALL
3
Q
BCL-2
A
Antiapoptotic molecule (inhibits apoptosis) --Follicular and diffuse large beta cell lymphomas
4
Q
BRAF
A
Serine/threonine kinase
–Melanoma, non-Hodgkin lymphoma
5
Q
c-KIT
A
Cytokine receptor
–Gastrointestinal stromal tumor (GIST)
6
Q
c-MYC
A
Transcription factor
–Burkitt lymphoma
7
Q
HER2/neu (c-erbB2)
A
Tyrosine kinase
–Breast and gastric carrcinomas
8
Q
JAK2
A
Chronic myeloproliferative disorders
9
Q
KRAS
A
GTPase
–Colon cancer, lung cancer, pancreatic cancer
10
Q
MTCL1
A
Transcription factor
–Lung tumor
11
Q
MYCN
A
Transcription factor
– Neuroblastoma
12
Q
RET
A
Tyrosine kinase
–MEN 2A and 2B, medullary thyroid cancer
13
Q
APC
A
Colorectal cancer (associated with FAP)
14
Q
BRCA1/BRCA2
A
Breast and ovarian cancer
–DNA repair protein
15
Q
CDKN2A
A
Melanoma, pancreatic cancer
– p16, blocks G1-> S phase
