First Aid - Oncogens and Tumor Suppessor Genes Flashcards
ALK
Receptor tyrosine kinase
–Lung adenocarcinoma
BCR-ABL
Tyrosine kinase
– CML, ALL
BCL-2
Antiapoptotic molecule (inhibits apoptosis) --Follicular and diffuse large beta cell lymphomas
BRAF
Serine/threonine kinase
–Melanoma, non-Hodgkin lymphoma
c-KIT
Cytokine receptor
–Gastrointestinal stromal tumor (GIST)
c-MYC
Transcription factor
–Burkitt lymphoma
HER2/neu (c-erbB2)
Tyrosine kinase
–Breast and gastric carrcinomas
JAK2
Chronic myeloproliferative disorders
KRAS
GTPase
–Colon cancer, lung cancer, pancreatic cancer
MTCL1
Transcription factor
–Lung tumor
MYCN
Transcription factor
– Neuroblastoma
RET
Tyrosine kinase
–MEN 2A and 2B, medullary thyroid cancer
APC
Colorectal cancer (associated with FAP)
BRCA1/BRCA2
Breast and ovarian cancer
–DNA repair protein
CDKN2A
Melanoma, pancreatic cancer
– p16, blocks G1-> S phase
DCC
Colon cancer
–DCC - Deleted in Colon Cancer
DPC4/SMAD4
Pancreatic cancer
– DPC - Deleted in Pancreatic Cancer
MEN1
MEN 1
–Menin
NF1
NeuroFibromatosis type 1
–Ras GTPase activating protein (neurofibromin)
NF2
NeuroFibromatosis type 2
–Merlin (schwannomin) protein
PTEN
Breast cancer, prostate cancer, endometrial cancer
Rb
Retinoblastoma, osteosarcoma
–Inhibits E2F; blocks G1 -> S phase
TP53
Most human cancers, Li-Fraumeni syndrome
–p53, activates p21, blocks G1 -> S phase
TSC1
Tuberous sclerosis
–Hamartin protein
TSC2
Tuberous sclerosis
– Tuberin protein
VHL
von Hippel-Lindau disease, renal cell carcinoma
– Inhibits hypoxia inducible factor 1a
WT1/WT2
Wilms Tumor (nephroblastoma)
