Pharm- Anti-emetics

Question 1

How can antihistaminergic agents suppress nausea by wroking in the brain?

Answer 1

The inhibit signals from the vestibular nucleus in the vomiting center in the medulla

Question 2

Why is proclorperazine contraindicated in pregnant women?

Answer 2

The safety of the drug has not been established

Question 3

Prochlorperazine inhibits vomiting as a sid effect of what parkinsons drug?

Answer 3

Apomorphine

Question 4

Prochlorperazine also blocks dopamine receptors in which area of the medulla?

Answer 4

chemoreceptor trigger zone (CTZ)

Question 5

This is the class of drugs which enhance GI motility by increasing the frequency of contractions and strength in the small intestine

Answer 5

Prokinetic agents

Question 6

Which drug is both a prokinetic and dopamine-R antagonist and entiemetic?

Answer 6

Metaclopramide

Question 7

Where in the brainstem is the area postrema?

Answer 7

Floor of the 4th ventricle

lol neuroanatomy.

Question 8

Which type of dopamine receptors are in the area postrema?

Answer 8

D2

Question 9

Which type of serotonin receptors are in the area postrema?

Answer 9

5HT3